88335-90-4

Basic information

• Product Name: (1R,2S)-cis-2-methoxycarbonyl-cyclopentane-1-carboxylic acid
• Synonyms: (1R,2S)-cis-2-methoxycarbonyl-cyclopentane-1-carboxylic acid
• CAS NO: 88335-90-4
• Molecular Weight: 172.181
• Mol File: 88335-90-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R,2S)-cis-2-methoxycarbonyl-cyclopentane-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-cis-2-methoxycarbonyl-cyclopentane-1-carboxylic acid(88335-90-4)
• EPA Substance Registry System: (1R,2S)-cis-2-methoxycarbonyl-cyclopentane-1-carboxylic acid(88335-90-4)

Safety Data

• Hazardous Substances Data: 88335-90-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 35878-28-5 cyclopentane-cis-1,2-dicarboxylic acid anhydride 
• 1461-96-7 cis-1,2-cyclopentanedicarboxylic acid 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 80656-14-0 trans-1,2-cyclopentanedicarboxylic acid 

Downstream Products

• 1445590-56-6 (1,2-trans)-N-benzyl-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxamide 
• 1445589-44-5 methyl ((S)-1-((S)-2-(5-(4-(2-((1S,2S)-2-(3,3-dimethylmorpholine-4-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1445589-43-4 methyl ((S)-3-methyl-1-((S)-2-(5-(4-(2-((1S,2S)-2-((R)-2-methylpiperidine-1-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate 
• 1445589-42-3 methyl ((S)-3-methyl-1-((S)-2-(5-(4-(2-((1S,2S)-2-((S)-2-methylpiperidine-1-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate 
• 1445589-35-4 methyl ((S)-3-methyl-1-((S)-2-(5-(4-(2-((1R,2R)-2-((S)-2-methylpyrrolidine-1-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate 
• 1445590-90-8 ((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone 
• 1445597-10-3 methyl ((S)-1-((2S,4S)-4-methoxy-2-(5-(4-(2-((1R,2R)-2-((R)-3-methylmorpholine-4-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1445590-85-1 (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid 
• 1445590-78-2 (1R,2 R)-2-(5-(4'-(2-((S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid 
• 1445591-94-5 (1R,2R)-tert-butyl 2-(5-(4'-(2-((S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylate 

Relevant articles and documents

Practical and Highly Enantioselective Ring Opening of Cyclic Meso-Anhydrides Mediated by Cinchona Alkaloids

The cinchona alkaloid-mediated opening of prochiral cyclic anhydrides in the presence of methanol leading to optically active hemiesters is described. Very structurally diverse anhydrides are converted into their corresponding methyl monoesters, and either enantiomer can be obtained with up to 99% ee by using quinine or quinidine as directing additive. After the reaction, the alkaloids can be recovered almost quantitatively and reused without loss of enantioselectivity. Additionally, a catalytic protocol which permits the substoichiometric use of quinidine in the presence of easily accessible pentamethylpiperidine (pempidine) is presented.

A highly enantioselective catalytic desymmetrization of cyclic anhydrides with modified cinchona alkaloids [3]

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