883442-71-5

Basic information

• Product Name: 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-oxo-, 1,1-dimethylethyl ester, (5R)-
• CAS NO: 883442-71-5
• Molecular Formula: C39H42F2N2O5
• Molecular Weight: 656.77
• Mol File: 883442-71-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-oxo-, 1,1-dimethylethyl ester, (5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-oxo-, 1,1-dimethylethyl ester, (5R)-(883442-71-5)
• EPA Substance Registry System: 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-oxo-, 1,1-dimethylethyl ester, (5R)-(883442-71-5)

Safety Data

• Hazardous Substances Data: 883442-71-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 620-72-4 phenyl 2-bromoacetate 

Downstream Products

• 883446-53-5 (2R,5R)-5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-cyclohexylmethoxymorpholine-4-carboxylic acid tert-butyl ester 
• 883442-72-6 (3S,5R)-5-{(1S,2S)-2-Dibenzylamino-3-[3,5-difluorophenyl]-1-benzyloxy-propyl}-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester 
• 883443-02-5 (3S,5R)-5-[(1S,2S)-1-benzyloxy-2-dibenzylamino-3-(3,5-difluoro-phenyl)-propyl]-3-ethyl-2-oxomorpholine-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences

NMR conformational analysis of a hydroxyethylamine peptide isostere developed as an aspartic protease inhibitor shows that it is a flexible architecture. Cyclization to form pyrrolidines, piperidines, or morpholines results in a preorganization of the who