88347-44-8

Basic information

• Product Name: Acetic acid, [(6-phenyl-2-pyridinyl)oxy]-
• CAS NO: 88347-44-8
• Molecular Formula: C13H11NO3
• Molecular Weight: 229.235
• Mol File: 88347-44-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid, [(6-phenyl-2-pyridinyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [(6-phenyl-2-pyridinyl)oxy]-(88347-44-8)
• EPA Substance Registry System: Acetic acid, [(6-phenyl-2-pyridinyl)oxy]-(88347-44-8)

Safety Data

• Hazardous Substances Data: 88347-44-8(Hazardous Substances Data)

Upstream product

• 19006-82-7 6-phenyl-2-pyridone 
• 337969-46-7 ethyl 2-(6-phenyl-2-pyridyloxy)acetate 

Downstream Products

• 337969-42-3 N-[(1S)-2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-2-hydroxy-1-(methylethyl)ethyl]-2-(6-phenyl-2-pyridyloxy)acetamide 

Relevant articles and documents

Development of orally active nonpeptidic inhibitors of human neutrophil elastase

5-Amino-2-phenylpyrimidin-6-ones, some of their desamino derivatives, and miscellaneous derivatives were synthesized and biologically evaluated on both in vitro activity and oral activity in an acute hemorrhagic assay. These compounds contained an α-keto-1,3,4-oxadiazole moiety to bind covalently to the Ser-195 hydroxy group of human neutrophil elastase (HNE). Among those tested, compounds 11a-c,e,i-l(F), 11d,e,k(H), 21d,e,k(F), and 21d,e(H) showed a good oral profile. RS-Mixture 3(H) was selected for clinical evaluation based on its oral potency, duration of action, enzyme selectivity, safety profile, and ease of synthesis. Structure -activity relationships (SARs) are discussed.