88496-70-2Relevant articles and documents
Highly enantioselective bioreduction of prochiral ketones by stem and germinated plant of Brassica oleracea variety italica
Mohammadi, Mehdi,Yousefi, Maryam,Habibi, Zohreh
experimental part, p. 328 - 336 (2012/03/11)
An eco-friendly and environmentally benign asymmetric reduction of a broad range of prochiral ketones employing Brassica oleracea variety italica (stems and germinated plant) as a novel biocatalyst was developed. It was found that B. oleracea variety italica could be used effectively for enantioselective bioreduction in aqueous medium with moderate to excellent chemical yield and enantiomeric excess (ee). This process is more efficient and generates less waste than conventional chemical reagents or microorganisms. Both R- and S-configurations were obtained by these asymmetric reactions. The best ee were achieved for pyridine derivatives (92-99%). The ee in germinated plant reactions were significantly higher than those of stem reactions. The low cost and the easy availability of these biocatalysts suggest their possible use for large scale preparations of important chiral alcohols.
Tandem concurrent processes: One-pot single-catalyst biohydrogen transfer for the simultaneous preparation of enantiopure secondary alcohols
Bisogno, Fabricio R.,Lavandera, Ivan,Kroutil, Wolfgang,Gotor, Vicente
supporting information; scheme or table, p. 1730 - 1732 (2009/07/11)
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Sequential kinetic resolution catalyzed by halohydrin dehalogenase
Elenkov, Maja Majeric,Tang, Lixia,Hauer, Bernhard,Janssen, Dick B.
, p. 4227 - 4229 (2007/10/03)
(Chemical Equation Presented) A sequential kinetic resolution catalyzed by halohydrin dehalogenase was employed for the synthesis of two valuable enantiopure building blocks. Resolution of methyl 4-chloro-3-hydroxybutanoate methylester ((R,S)-2) with use of a Trp249Phe mutant of halohydrin dehalogenase yielded methyl 4-cyano-3-hydroxybutanoate methylester ((S)-4) with 96.8% ee (40% yield) and (S)-2 with 95.2% ee (41% yield). This reaction is carried out in aqueous solution under mild conditions and provides access to a useful statin side-chain building block.