885125-90-6Relevant articles and documents
Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors
Palmer, James T.,Rydzewski, Robert M.,Mendonca, Rohan V.,Sperandio, David,Spencer, Jeffrey R.,Hirschbein, Bernard L.,Lohman, Julia,Beltman, Jeri,Nguyen, Margaret,Liu, Liang
, p. 3434 - 3439 (2007/10/03)
Using a scaleable, directed library approach based on orthogonally protected advanced intermediates, we have prepared a series of potent keto-1,2,4-oxadiazoles designed to explore the P2 binding pocket of human mast cell tryptase, while buildin