885274-50-0 Usage
Description
1-Cbz-2-(2-Oxoethyl)Piperidine, also known as Cbz-2-acetamidomethylpiperidine, is a piperidine derivative featuring a Cbz (carboxybenzyl) protecting group at the 1-position and a 2-oxoethyl group at the 2-position. This chemical compound serves as a versatile building block in organic synthesis and holds significant potential in the development of pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
1-Cbz-2-(2-Oxoethyl)Piperidine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the creation of complex molecular structures. Its presence as a building block allows for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Cbz-2-(2-Oxoethyl)Piperidine is utilized as a precursor in the production of bioactive compounds, contributing to the advancement of crop protection agents and other agricultural chemicals. Its role in synthesizing these compounds helps in enhancing crop yields and managing pests.
Used in Organic Synthesis:
1-Cbz-2-(2-Oxoethyl)Piperidine is employed as a fundamental component in organic synthesis, where it aids in the construction of intricate organic molecules. Its unique structure allows for the development of a wide range of chemical entities with diverse applications.
Used in Medicinal Chemistry Research:
As a compound with potential pharmacological properties, 1-Cbz-2-(2-Oxoethyl)Piperidine is used in medicinal chemistry for investigating its therapeutic potential. It serves as a valuable tool for understanding the structure-activity relationships of various biologically active molecules.
Used in the Synthesis of Complex Natural Products:
1-Cbz-2-(2-Oxoethyl)Piperidine is also used as a precursor in the synthesis of complex natural products, enabling the production of compounds with unique biological activities. Its role in this process aids researchers in exploring new avenues for drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 885274-50-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,7 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 885274-50:
(8*8)+(7*8)+(6*5)+(5*2)+(4*7)+(3*4)+(2*5)+(1*0)=210
210 % 10 = 0
So 885274-50-0 is a valid CAS Registry Number.
885274-50-0Relevant articles and documents
Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols
Gómez, Livia,Garrabou, Xavier,Joglar, Jesús,Bujons, Jordi,Parella, Teodor,Vilaplana, Cristina,Cardona, Pere Joan,Clapés, Pere
, p. 6309 - 6321 (2012/09/05)
The synthesis, conformational study and inhibitory properties of diverse indolizidine and quinolizidine iminocyclitols are described. The compounds were chemo-enzymatically synthesized by two-step aldol addition and reductive amination reactions. The aldol addition of dihydroxyacetone phosphate (DHAP) to N-Cbz-piperidine carbaldehyde derivatives catalyzed by l-rhamnulose 1-phosphate aldolase from Escherichia coli provides the key intermediates. The stereochemical outcome of both aldol addition and reductive amination depended upon the structure of the starting material and intermediates. The combination of both reactions furnished five indolizidine and six quinolizidine type iminocyclitols. A structural analysis by NMR and in silico density functional theory (DFT) calculations allowed us to determine the population of stereoisomers with the trans or cis ring fusion, as a consequence of the inversion of configuration of the bridgehead nitrogen. The trans fusion was by far the most stable, but for certain stereochemical configurations of the 3-hydroxymethyl and hydroxyl substituents both trans and cis fusion stereoisomers coexisted in different proportions. Some of the polyhydroxylated indolizidines and quinolizidines were shown to be moderate to good inhibitors against α-l-rhamnosidase from Penicillium decumbens. Indolizidines were found to be moderate inhibitors of the rat intestinal sucrase and of the exoglucosidase amyloglucosidase from Aspergillus niger. In spite of their activity against α-l-rhamnosidase, all the compounds were ineffective to inhibit the growth of the Mycobacterium tuberculosis, the causative agent of tuberculosis. The Royal Society of Chemistry 2012.
