885278-74-0 Usage
Description
ETHYL 1H-INDAZOLE-7-CARBOXYLATE is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its indazole core structure and carboxylate functional group, which allows for further chemical modifications and the development of potential therapeutic agents.
Uses
Used in Pharmaceutical Industry:
ETHYL 1H-INDAZOLE-7-CARBOXYLATE is used as a synthetic intermediate for the development of pyrrolopyrazine derivatives. These derivatives have potential applications as selective spleen tyrosine kinase inhibitors, which can be beneficial in the treatment of various inflammatory and autoimmune diseases.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, ETHYL 1H-INDAZOLE-7-CARBOXYLATE is utilized for the synthesis of novel compounds with potential therapeutic properties. Its unique structure and functional groups make it a valuable building block for designing and optimizing new drug candidates.
Used in Drug Discovery:
ETHYL 1H-INDAZOLE-7-CARBOXYLATE plays a crucial role in drug discovery processes, where it is employed to create new chemical entities with potential biological activities. Its versatility in chemical reactions allows researchers to explore various structural modifications, leading to the identification of promising drug candidates for further development and clinical evaluation.
Check Digit Verification of cas no
The CAS Registry Mumber 885278-74-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,7 and 8 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 885278-74:
(8*8)+(7*8)+(6*5)+(5*2)+(4*7)+(3*8)+(2*7)+(1*4)=230
230 % 10 = 0
So 885278-74-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2O2/c1-2-14-10(13)8-5-3-4-7-6-11-12-9(7)8/h3-6H,2H2,1H3,(H,11,12)
885278-74-0Relevant articles and documents
Identification of novel protein kinase ck2 inhibitors among indazolderivatives
Bdzhola, V. G.,Borovykov, O. V.,Borysenko, I. P.,Lukashov, S. S.,Protopopov, M. V.,Vdovin, V. S.,Yarmoluk, S. M.
, p. 177 - 184 (2021/10/22)
Aim. To synthesize the novel purine bioisosteres — indazole derivatives and evaluate inhibitory activity of these compounds towards CK2 in the in vitro system. Methods. Chemical synthesis,1H and13C NMR spectroscopy, LC-MS method, determination of residual enzyme activity using ATP consumption tests with a luciferase Kinase-Glo luminescent kinase assay. Results. Known synthetic methods of indazole chemistry were originally applied to the synthesis of 3-aryl-indazole-7-carboxylic acids. Conditions of cross-coupling of 3-bromo-indazole derivatives with arylboronic acids were substantially improved. 3-aryl-indazole 5-and 7-carboxylic acids have shown IC50 in a range 3.1–6.5 μM in luciferase luminescent kinase assay. Conclusions. The synthesis of 3-aryl-indazole-7-carboxylic acids has been developed. Novel inhibitors of the protein kinase CK2 among indazole derivatives have been identified among the 3-aryl-indazole 5-and 7-carboxylic acids. It has been shown the crucial impact of carboxyl group on the inhibitory activity of studied compounds.
