885279-01-6

Basic information

• Product Name: METHYL 5,6-DIFLUORO-1H-INDAZOLE-3-CARBOXYLATE
• Synonyms: 1H-Indazole-3-carboxylic acid, 5,6-difluoro-, Methyl ester;METHYL 5,6-DIFLUORO-1H-INDAZOLE-3-CARBOXYLATE
• CAS NO: 885279-01-6
• Molecular Formula: C9H6F2N2O2
• Molecular Weight: 212.15
• Mol File: 885279-01-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL 5,6-DIFLUORO-1H-INDAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5,6-DIFLUORO-1H-INDAZOLE-3-CARBOXYLATE(885279-01-6)
• EPA Substance Registry System: METHYL 5,6-DIFLUORO-1H-INDAZOLE-3-CARBOXYLATE(885279-01-6)

Safety Data

• Hazardous Substances Data: 885279-01-6(Hazardous Substances Data)

Usage

General Description

Methyl 5,6-difluoro-1H-indazole-3-carboxylate is a chemical compound with the molecular formula C9H6F2N2O2. It is a fluorescent compound that is commonly used in research and development, particularly in the pharmaceutical and agrochemical industries. METHYL 5,6-DIFLUORO-1H-INDAZOLE-3-CARBOXYLATE is known for its potential biological activities, including antifungal and antibacterial properties. It is often used as a building block in the synthesis of various pharmaceutical products and agrochemicals due to its unique structure and reactivity. Additionally,

Upstream product

• 67-56-1 methanol 
• 774-47-0 5,6-difluoro-1H-indole-2,3-dione 

Relevant articles and documents

Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structure-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides

Our studies on 4-amino-5-chloro-2-ethoxybenzamides led to the discovery that the N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)benzamide 9 and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 10 are potent serotonin-3 (5-HT3) receptor antagonists. Structure-activity relationship (SAR) studies on the influence of the aromatic nucleus of 9 and 10 upon inhibition of the von Bezold-Jarisch reflex in rats are described. Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridaziae, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity. Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H- indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity. The optimal compound identified via extensive SAR studies was N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole- 3-carboxamide (54), whose effect was superior to that of the corresponding benzamide 10 and essentially equipotent to those of ondansetron (1) and granisetron (4).