886363-28-6 Usage
General Description
4-(5'-indole)phenyl acetic acid, also known as indolic phenyl acetic acid (IPAA), is a chemical compound that belongs to the class of indole derivatives. It is synthesized by the substitution reaction of 4-aminobenzophenone with indole-3-acetonitrile, and it is commonly used in the pharmaceutical and agricultural industries. IPAA has been found to possess anti-inflammatory, analgesic, and antipyretic properties, and it has been investigated for its potential therapeutic applications in the treatment of various diseases, including cancer and neurodegenerative disorders. Additionally, IPAA has been shown to exhibit herbicidal activity, making it a valuable compound for the development of new agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 886363-28-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,3,6 and 3 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 886363-28:
(8*8)+(7*8)+(6*6)+(5*3)+(4*6)+(3*3)+(2*2)+(1*8)=216
216 % 10 = 6
So 886363-28-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H13NO2/c18-16(19)9-11-1-3-12(4-2-11)13-5-6-15-14(10-13)7-8-17-15/h1-8,10,17H,9H2,(H,18,19)
886363-28-6Relevant articles and documents
Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors
Pu, Chunlan,Luo, Rong-Hua,Zhang, Mengqi,Hou, Xueyan,Yan, Guoyi,Luo, Jiang,Zheng, Yong-Tang,Li, Rui
, p. 4150 - 4155 (2017/08/22)
The crystal structure of viral infectivity factor (Vif) was reported recently, which makes it possible to design new inhibitors against Vif by structure-based drug design. Through analysis of the protein surface of Vif, the C2 pocket located in the N-terminal was found, which is suit for developing small molecular inhibitors. Then, in our article, fragment-based virtual screening (FBVS) was conducted and a series of fragments was obtained, among which, Zif-1 bearing indole scaffold and pyridine ring can form H-bonds with Tyr148 and Ile155. Subsequently, 19 derivatives of Zif-1 were synthesized. Through the immune-fluorescence staining and Western blot assays, Zif-15 shows potent activity in inhibiting Vif-mediated A3G degradation. Further docking experiment shows that Zif-15 form H-bond interactions with residues His139, Tyr148 and Ile155. Therefore, Zif-15 is a promising lead compound against Vif that can be used to treat AIDS.
