886371-78-4

Basic information

• Product Name: 4-FLUORO-PYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 4-FLUORO-PYRIDINE-2-CARBOXYLIC ACID;4-Fluoro-2-pyridinecarboxylic acid;4-fluoropicolinic acid
• CAS NO: 886371-78-4
• Molecular Formula: C₆H₄FNO₂
• Molecular Weight: 141.0998632
• Mol File: 886371-78-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 292.3 °C at 760 mmHg
• Flash Point: 130.6 °C
• Appearance: /
• Density: 1.419
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.39±0.10(Predicted)
• CAS DataBase Reference: 4-FLUORO-PYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-PYRIDINE-2-CARBOXYLIC ACID(886371-78-4)
• EPA Substance Registry System: 4-FLUORO-PYRIDINE-2-CARBOXYLIC ACID(886371-78-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 886371-78-4(Hazardous Substances Data)

Usage

General Description

4-Fluoro-pyridine-2-carboxylic acid is a chemical compound with the molecular formula C6H4FNO2. It is a derivative of pyridine, with a fluorine atom attached to the fourth carbon in the ring and a carboxylic acid functional group attached to the second carbon. 4-FLUORO-PYRIDINE-2-CARBOXYLIC ACID is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various organic compounds, including pharmaceutical drugs and agricultural pesticides. 4-Fluoro-pyridine-2-carboxylic acid is a versatile intermediate in organic synthesis and has potential applications in drug discovery and development.

Upstream product

• 98-98-6 2-Picolinic acid 

Downstream Products

• 1172938-55-4 4-fluoropyridine-2-carboxamide 

Relevant articles and documents

Synthesis method of 2-amino-4-fluoropyridine

The invention discloses a synthesis method of 2-amino-4-fluoropyridine, the synthesis method specifically comprises the following steps: 1. reacting 2-pyridine carboxylic acid used as a raw material in the presence of a catalyst, fluoride and an oxidant to obtain 4-fluoropyridine-2-formic acid; 2, reacting the 4-fluoropyridine-2-formic acid with chloroformate, organic alkali, an ammonia source andthe like to generate 4-fluoropyridine-2-formamide; 3, carrying out a Hofmann amide degradation reaction on the 4-fluoropyridine-2-formamide to obtain 2-amino-4-fluoropyridine; the synthesis of the 2-amino-4-fluoropyridine is realized by taking the obtained 2-pyridine carboxylic acid as a raw material at a low price through less three steps. Reagents used in the reaction process are cheap and easyto obtain, the reaction process is short in step, easy and convenient to operate, high in yield, safe to operate and free of pollution and the method suitable for industrial production.