886599-21-9Relevant articles and documents
Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3
Smalley Jr., Terrence L.,Peat, Andrew J.,Boucheron, Joyce A.,Dickerson, Scott,Garrido, Dulce,Preugschat, Frank,Schweiker, Stephanie L.,Thomson, Stephen A.,Wang, Tony Y.
, p. 2091 - 2094 (2007/10/03)
A set of novel heterocyclic pyrimidyl hydrazones has been synthesized as inhibitors of glycogen synthase kinase-3 (GSK-3) with the most active exhibiting low nanomolar activity. Quantum mechanical calculations indicate that of the conformational factors t