888729-56-4Relevant articles and documents
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity
Chellappan, Sheela K.,Xiao, Yingxian,Tueckmantel, Werner,Kellar, Kenneth J.,Kozikowski, Alan P.
, p. 2673 - 2676 (2007/10/03)
We report the synthesis and pharmacological properties of several cytisine derivatives. Among them, two 10-substituted derivatives showed much higher selectivities for the α4β2 nAChR subtype in binding assays than cytisine. The 9-vinyl derivative was foun