889113-37-5

Basic information

• Product Name: 2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[(isopropylsulfonyl)(methyl)amino]isonicotinic acid
• Synonyms: 2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[(isopropylsulfonyl)(methyl)amino]isonicotinic acid
• CAS NO: 889113-37-5
• Molecular Weight: 431.556
• Mol File: 889113-37-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[(isopropylsulfonyl)(methyl)amino]isonicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[(isopropylsulfonyl)(methyl)amino]isonicotinic acid(889113-37-5)
• EPA Substance Registry System: 2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[(isopropylsulfonyl)(methyl)amino]isonicotinic acid(889113-37-5)

Safety Data

• Hazardous Substances Data: 889113-37-5(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 6142-57-0 (+/-)-trans-2-methylcyclopropanecarboxylic acid 
• 42521-09-5 methyl 2,6-dichloroisonicotinate 
• 959774-49-3 (1S,2S)-N-benzyl-2-methylcyclopropane-1-carboxamide 
• 935470-34-1 methyl 2-chloro-6-[(isopropylsulfonyl)(methyl)amino]isonicotinate 
• 935470-36-3 2-chloro-6-[(isopropylsulfonyl)(methyl)amino]isonicotinic acid 

Downstream Products

• 946420-65-1 N-[(1S,2R)-2-azido-1-benzyl-3-fluoropropyl]-2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[(isopropylsulfonyl)(methyl)amino]isonicotinamide 

Relevant articles and documents

Discovery of isonicotinamide derived β-secretase inhibitors: In vivo reduction of β-amyloid

β-Secretase inhibition offers an exciting opportunity for therapeutic intervention in the progression of Alzheimer's disease. A series of isonicotinamides derived from traditional aspartyl protease transition state isostere inhibitors has been optimized to yield low nanomolar inhibitors with sufficient penetration across the blood-brain barrier to demonstrate β-amyloid lowering in a murine model.