889359-32-4

Basic information

• Product Name: 6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one
• Synonyms: 6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one
• CAS NO: 889359-32-4
• Molecular Weight: 499.608
• Mol File: 889359-32-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one(889359-32-4)
• EPA Substance Registry System: 6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one(889359-32-4)

Safety Data

• Hazardous Substances Data: 889359-32-4(Hazardous Substances Data)

Upstream product

• 20776-50-5 2-amino-4-bromobenzoic acid 
• 852620-80-5 2-azido-4-bromo-N-(4-(trifluoromethyl)phenyl)benzamide 
• 852620-82-7 1,2-dihydro-6-bromo-2-(4-trifluoromethylphenyl)-3H-indazol-3-one 
• 852620-81-6 6-bromo-3-chloro-2-(4-trifluoromethylphenyl)-2H-indazole 
• 852620-79-2 2-azido-4-bromobenzoic acid 
• 852620-83-8 6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one 
• 18368-76-8 2 chloro-3-methylpyridine 

Relevant articles and documents

The search for novel TRPV1-antagonists: From carboxamides to benzimidazoles and indazolones

Based on a series of diaryl amides the corresponding inverse amides have been found to be potent TRPV1 receptor antagonists. Benzimidazole and indazolone derivatives prepared retained good potency in vitro and indazolone 4a was identified as a novel TRPV1 receptor antagonist suitable for evaluating orally in animal models of analgesia.