889447-19-2

Basic information

• Product Name: 2-chloro-5H-pyrrolo[2,3-b]pyrazine
• Synonyms: 2-chloro-5H-pyrrolo[2,3-b]pyrazine;2-Chloro-5H-pyrrolo[2,3-b...;2-chloro-5H-pyrrolo[2;5H-Pyrrolo[2,3-b]pyrazine, 2-chloro-;2-chloro-5H-pyrrolo[3,2-b]pyrazine
• CAS NO: 889447-19-2
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.5691
• Product Categories: CHIRAL CHEMICALS
• Mol File: 889447-19-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.531 g/cm³
• Refractive Index: 1.72
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.63±0.50(Predicted)
• CAS DataBase Reference: 2-chloro-5H-pyrrolo[2,3-b]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5H-pyrrolo[2,3-b]pyrazine(889447-19-2)
• EPA Substance Registry System: 2-chloro-5H-pyrrolo[2,3-b]pyrazine(889447-19-2)

Safety Data

• Hazardous Substances Data: 889447-19-2(Hazardous Substances Data)

Usage

General Description

2-chloro-5H-pyrrolo[2,3-b]pyrazine is a chemical compound that falls under the category of pyrrolopyrazines, substances known for their versatile chemical properties. Due to its chlorine atom, it is reactive and can participate in a range of chemical reactions. The compound also contains characteristics of both pyrrole and pyrazine, two nitrogen-containing heterocyclic compounds. However, detailed information about its specific uses, toxicity, or production is not readily available, likely indicating that it is predominantly used in specialized or research contexts.

InChI:InChI=1/C6H4ClN3/c7-5-3-9-6-4(10-5)1-2-8-6/h1-3H,(H,8,9)

Upstream product

• 889447-18-1 5-chloro-3-(triethyl-silanylethynyl)-pyrazin-2-ylamine 
• 1244776-64-4 5-chloro-3-((trimethylsilyl)ethynyl)pyrazine-2-amine 
• 875781-43-4 2-bromo-5H-pyrrolo[2,3-b]pyrazine 

Downstream Products

• 889447-20-5 2-chloro-7-iodo-5H-pyrrolo[2,3-b]pyrazine 
• 1262310-65-5 2-chloro-7-iodo-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine 
• 1262310-67-7 trans-4-(6-chloro-4-(2-chloro-5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-ylamino)cyclohexanol 
• 1262310-64-4 trans-4-{[6-chloro-4-(2-chloro-5H-pyrrolo[2,3-b]pyrazin-7-yl)pyridin-2-yl]amino}cyclohexanol 

Relevant articles and documents

INDOLE AND AZAINDOLE COMPOUNDS WITH SUBSTITUTED 6-MEMBERED ARYL AND HETEROARYL RINGS AS AGROCHEMICAL FUNGICIDES

The present invention relates to heteroaryl compounds of formula (Ia) or a compound in the form of a stereoisomer, an agriculturally acceptable salt, a tautomer,an isotopic form, a N-oxide or a S-oxide thereof. The present invention further relates to the use of a compound of formula (I) or an agriculturally acceptable salt, a stereoisomer, a tautomer, an isotopic form, a derivative or mixture thereof, as fungicide.

INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF

The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Compounds used as JAK inhibitor, and use of compounds

The invention provides compounds used as a JAK inhibitor, and a use of the compounds, and concretely provides compounds (represented by formula (I)) with JAK inhibition activity or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and a medicinal composition including the compounds. The invention also discloses a use of the compounds or the medicinal composition thereof in the preparation of medicines used for treating autoimmune diseases or proliferative diseases.