88975-08-0Relevant articles and documents
Method for preparing flurbiprofen impurity M
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Paragraph 0039; 0040, (2018/09/14)
The invention discloses a method for preparing a flurbiprofen impurity M. The method adopts 3,4-difluoronitrobenzene as an initial raw material to have substitution reaction with diethyl methylmalonate, and the flurbiprofen impurity M with high purity is
Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2- oxocyclopentyl)methyl]phenyl}propanoic acid: Nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity
Yamakawa, Naoki,Suemasu, Shintaro,Okamoto, Yoshinari,Tanaka, Ken-Ichiro,Ishihara, Tomoaki,Asano, Teita,Miyata, Keishi,Otsuka, Masami,Mizushima, Tohru
supporting information; experimental part, p. 5143 - 5150 (2012/09/07)
We previously reported that 2-fluoroloxoprofen has lower gastric ulcerogenic activity than loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID) without selectivity for COX-2. We synthesized derivatives of 2-fluoroloxoprofen and studied their properti