88979-61-7

Basic information

• Product Name: BAFILOMYCIN C1
• Synonyms: BAFILOMYCIN C1;2-Demethyl-2-methoxy-24-methylhygrolidin;Antibiotic L-681110A1;L-681110A1
• CAS NO: 88979-61-7
• Molecular Formula: C39H60O12
• Molecular Weight: 720.89
• Mol File: 88979-61-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 844.4 °C at 760 mmHg
• Flash Point: 248.9 °C
• Appearance: Light tan solid
• Density: 1.18 g/cm³
• Vapor Pressure: 3.79E-33mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: BAFILOMYCIN C1(CAS DataBase Reference)
• NIST Chemistry Reference: BAFILOMYCIN C1(88979-61-7)
• EPA Substance Registry System: BAFILOMYCIN C1(88979-61-7)

Safety Data

• Hazardous Substances Data: 88979-61-7(Hazardous Substances Data)

Usage

Description

Bafilomycin C1 is a potent macrocyclic lactone that belongs to a family of compounds with broad-spectrum activity against various organisms, including bacteria, fungi, insects, nematodes, and cestodes. It is structurally similar to its more accessible A1 analogue and has garnered interest as a potential agent for treating osteoporosis. The presence of the fumarate group in Bafilomycin C1 makes it an ideal ligand for affinity chromatography of V-ATPase.

Uses

Used in Pharmaceutical Industry:
Bafilomycin C1 is used as a potential therapeutic agent for treating osteoporosis due to its unique properties and mode of action.
Used in Research Applications:
Bafilomycin C1 is used as a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases) for studying the role of these pumps in mammalian, plant, or fungal cells. By blocking proton transport and compartment acidification, it helps researchers understand the functions and regulation of V-ATPases in various cellular processes.
Used in Angiogenesis Research:
Bafilomycin C1 is used as an angiostatic agent in the chick chorioallantoic membrane assay to study its effects on blood vessel formation and its potential applications in controlling angiogenesis-related diseases.
Used in Protein Purification:
Bafilomycin C1, when coupled to cellulose, is used as an affinity ligand for the purification of V-ATPases, aiding researchers in isolating and studying these proteins for their structure, function, and potential applications in drug development.

InChI:InChI=1/C39H60O12/c1-21(2)36-26(7)31(49-33(42)16-15-32(40)41)20-39(46,51-36)28(9)35(44)27(8)37-29(47-10)14-12-13-22(3)17-24(5)34(43)25(6)18-23(4)19-30(48-11)38(45)50-37/h12-16,18-19,21,24-29,31,34-37,43-44,46H,17,20H2,1-11H3,(H,40,41)/b14-12-,16-15+,22-13+,23-18+,30-19-/t24-,25+,26-,27-,28-,29-,31+,34-,35+,36+,37?,39+/m0/s1