89-38-3

Basic information

• Product Name: Pteroyltriglutamic
• Synonyms: Pteroyltriglutamic;2-[[4-[[4-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]pentanedioic acid;Pteroyltriglutamic acid;pteropterin;N-[N-[N-[4-[[(2-Amino-1,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]-L-γ-glutamyl]-L-γ-glutamyl]-L-glutamic acid;2-[[4-[[4-[[4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoyl]amino]-5-hydroxy-5-keto-pentanoyl]amino]-5-hydroxy-5-keto-pentanoyl]amino]glutaric acid;2-[[4-[[4-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]-5-hydroxy-5-oxopentanoyl]amino]-5-hydroxy-5-oxopentanoyl]amino]pentanedioic acid;2-[[4-[[4-[[4-[(2-azanyl-4-oxo-1H-pteridin-6-yl)methylamino]phenyl]carbonylamino]-5-hydroxy-5-oxo-pentanoyl]amino]-5-hydroxy-5-oxo-pentanoyl]amino]pentanedioic acid
• CAS NO: 89-38-3
• Molecular Formula: C₂₉H₃₃N₉O₁₂
• Molecular Weight: 669.648
• Mol File: 89-38-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.68±0.1 g/cm3(Predicted)
• Refractive Index: 1.691
• PKA: 3.39±0.10(Predicted)
• CAS DataBase Reference: Pteroyltriglutamic(CAS DataBase Reference)
• NIST Chemistry Reference: Pteroyltriglutamic(89-38-3)
• EPA Substance Registry System: Pteroyltriglutamic(89-38-3)

Safety Data

• Hazardous Substances Data: 89-38-3(Hazardous Substances Data)

Usage

Description

Pteroyltriglutamic acid, also known as folic acid or vitamin B9, is a water-soluble vitamin that plays a crucial role in various biological processes, including DNA synthesis, repair, and methylation. It is a folate derivative found in various foods such as yeast, spinach, beef liver, beef fillet, and peas.

Uses

Used in Pharmaceutical Industry:
Pteroyltriglutamic acid is used as a therapeutic agent for treating folic acid deficiency and its associated conditions, such as anemia, neural tube defects, and certain types of cancer. It is also used in combination with other vitamins and minerals to support overall health and well-being.
Used in Food and Beverage Industry:
Pteroyltriglutamic acid is used as a food additive and nutritional supplement to fortify various food products, such as cereals, bread, and pasta, with folic acid. This helps to ensure adequate intake of this essential vitamin, particularly for populations at risk of deficiency.
Used in Cosmetics Industry:
Pteroyltriglutamic acid is used in cosmetic products, such as skincare and hair care formulations, due to its potential benefits for skin health and hair growth. It is believed to promote collagen synthesis and improve skin elasticity, as well as support hair follicle health and reduce hair loss.
Used in Research and Development:
Pteroyltriglutamic acid is used in scientific research to study its role in various biological processes and its potential applications in the development of new drugs and therapies. It is also used as a research tool to investigate the mechanisms of action of folic acid and its derivatives in different cell types and organisms.

InChI:InChI=1/C29H33N9O12/c30-29-37-23-22(25(44)38-29)33-15(12-32-23)11-31-14-3-1-13(2-4-14)24(43)36-18(28(49)50)6-9-20(40)34-16(26(45)46)5-8-19(39)35-17(27(47)48)7-10-21(41)42/h1-4,12,16-18,31H,5-11H2,(H,34,40)(H,35,39)(H,36,43)(H,41,42)(H,45,46)(H,47,48)(H,49,50)(H3,30,32,37,38,44)/t16-,17-,18-/m0/s1

Upstream product

• 121175-95-9 (S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid 
• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 84793-07-7 Fmoc-Glu-OtBu 
• 124126-68-7 α-tert-butyl N-<(9-fluorenylmethoxy)oxy>carbonyl-L-glutamic anhydride 
• 63948-16-3 α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate 

Relevant articles and documents

Folate analogues. 33. Synthesis of folate and antifolate poly-γ-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cel

Representative examples of folate and antifolate poly-γ-glutamyl metabolites were synthesized via the [(9-fluorenylmethoxy)oxy]carbonyl (Fmoc) chemistry using the KH polyamide resin. Polyglutamate yields were consistently better in all cases compared to t