890123-54-3Relevant articles and documents
Synthesis of spiro[4.5]decane CF-ring analogues of 1α,25- dihydroxyvitamin D3
Schepens, Wim,Van Haver, Dirk,Vandewalle, Maurits,Bouillon, Roger,Verstuyf, Annemieke,De Clercq, Pierre J.
, p. 4247 - 4250 (2007/10/03)
(Chemical Equation Presented) A novel series of analogues of calcitriol (1) is developed featuring a spirocyclic central core resulting from C18/C21-connection and C15/ C16-deletion (2a, 2b). The synthesis of the key intermediate involves an Eschenmoser r
7-(2-CYCLOHEXYLIDENE-ETHYLIDENE)-SPIRO[5.5]UNDECANES USEFUL FOR MAKING PHARMACEUTICAL COMPOSITIONS
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Page/Page column 34-35, (2010/11/08)
The invention relates to novel analogues of the hormonally active metabolite of vitamin D3, and more specifically provides 7- (2-cyclohexylidene-ethylidene) -spiro [5.5] undecanes and methods for making them, as well as pharmaceutical compositions which c