890298-05-2

Basic information

• Product Name: C₁₅H₂₃N₃O₃
• Synonyms: C₁₅H₂₃N₃O₃
• CAS NO: 890298-05-2
• Molecular Weight: 293.366
• Mol File: 890298-05-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₂₃N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₂₃N₃O₃(890298-05-2)
• EPA Substance Registry System: C₁₅H₂₃N₃O₃(890298-05-2)

Safety Data

• Hazardous Substances Data: 890298-05-2(Hazardous Substances Data)

Upstream product

• 1630012-42-8 C₁₁H₁₂N₂O₃ 
• 109-73-9 N-butylamine 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 100256-94-8 4-propoxy-benzoic acid ethyl ester 
• 64328-60-5 4-propoxy-benzoic acid hydrazide 

Downstream Products

• 1630012-90-6 4-butyl-5-(4-propoxyphenyl)-2H-1,2,4-triazole-3(4H)-one 

Relevant articles and documents

Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.