890402-81-0

Basic information

• Product Name: dutogliptin
• Synonyms: dutogliptin;L-tartrate salt of (2R)-1-{7-[(9R)-pyrrolidin-9-ylamino]-acetyl}-pyrrolidine-2-boronic acid
• CAS NO: 890402-81-0
• Molecular Formula: C14H26BN3O9
• Molecular Weight: 391.186
• Mol File: 890402-81-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: dutogliptin(CAS DataBase Reference)
• NIST Chemistry Reference: dutogliptin(890402-81-0)
• EPA Substance Registry System: dutogliptin(890402-81-0)

Safety Data

• Hazardous Substances Data: 890402-81-0(Hazardous Substances Data)

Upstream product

• 923566-03-4 (2R)-1-{2-[(3R)-pyrrolidinylamino]-acetyl}-pyrrolidine-2-boronic acid (1S,2S,3R,5S)-pinanediol ester 
• 87-69-4 L-Tartaric acid 
• 98-80-6 phenylboronic acid 
• 852329-66-9 Dutogliptin 

Relevant articles and documents

Impurities of heterocyclic boronic acid compound and control method thereof

The invention provides impurities (I) and (II) of duogliptin L-tartrate and a preparation method thereof. The impurities (I) and (II) are oxidation impurities of the duogliptin L-tartrate, and are generated in the preparation and placement processes of the duogliptin L-tartrate. The invention also provides a method for controlling the contents of the impurities (I) and (II) while reducing the total impurities during industrial production of the duogliptin L-tartrate, so that the quality standard of the duogliptin L-tartrate is improved, and the medication safety of the duogliptin L-tartrate isguaranteed. In addition, the impurities (I) and (II) are used as reference standards or reference substances and can be used for quality control and research of duogliptin or L-tartrate crude drugs and/or preparations thereof.

METHODS OF PREPARING HETERCYCLIC BORONIC ACIDS AND DERIVATIVES THEREOF

In the context of synthesizing heterocyclic boronic acid compounds, a convergent synthetic methodology is particularly efficient for preparing boropyrrolidines and derivatives of boropyrrolidines.