89076-64-2

Basic information

• Product Name: 5-NITRO-2-PHENYLPYRIDINE
• Synonyms: 5-NITRO-2-PHENYLPYRIDINE;5-NITRO-2-METHYLANISOLE;(5-Nitropyridin-2-yl)benzene;3-Nitro-6-phenylpridine
• CAS NO: 89076-64-2
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.19
• Mol File: 89076-64-2.mol
• Article Data: 34

Chemical Properties

• Melting Point: 116-118°
• Boiling Point: 344.1 °C at 760 mmHg
• Flash Point: 161.9 °C
• Appearance: /
• Density: 1.252 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-NITRO-2-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-2-PHENYLPYRIDINE(89076-64-2)
• EPA Substance Registry System: 5-NITRO-2-PHENYLPYRIDINE(89076-64-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 89076-64-2(Hazardous Substances Data)

Usage

General Description

5-Nitro-2-phenylpyridine is a chemical compound with the molecular formula C11H8N2O2. It is a nitroaromatic compound that contains a pyridine ring and a phenyl group. 5-NITRO-2-PHENYLPYRIDINE is used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and other functional materials. It is also used as a reagent in chemical reactions to introduce the 5-nitro-2-phenylpyridine moiety into target molecules. The nitro group in this compound makes it reactive and allows it to participate in various chemical reactions like nitration, reduction, and coupling reactions, making it an important intermediate in the synthesis of various organic compounds.

Upstream product

• 14150-94-8 3,5-dinitro-1-methyl-2-pyridone 
• 98-86-2 acetophenone 
• 7196-01-2 4-(1-phenylvinyl)morpholine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 98-80-6 phenylboronic acid 
• 4487-59-6 2-bromo-5-nitropyridine 
• 108-86-1 bromobenzene 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 603-33-8 triphenylbismuthane 
• 100-58-3 phenylmagnesium bromide 
• 3433-56-5 1-(1-phenylvinyl)pyrrolidine 
• 4747-13-1 α-methoxystyrene 
• 30651-24-2 5-nitropicolinic acid 
• 71-43-2 benzene 

Downstream Products

• 849353-27-1 (6-phenylpyridin-3-yl)carbamic acid ter-butyl ester 
• 126370-67-0 6-phenylpyridin-3-amine 
• 1335110-50-3 5-nitro-2,4-diphenylpyridine 
• 1332586-73-8 N-(6-phenylpyridin-3-yl)-4-sulfamoylbenzamide 
• 1332586-74-9 4-cyano-N-(6-phenylpyridin-3-yl)benzamide 
• 1344663-90-6 3-nitro-6-phenyl-2-p-tolylpyridine-1-oxide 
• 1344663-91-7 3-nitro-2-isopropyl-6-phenylpyridine-1-oxide 
• 1344663-92-8 2-cyclohexyl-3-nitro-6-phenylpyridine-1-oxide 
• 1344663-50-8 2-phenyl-5-nitropyridine N-oxide 
• 1357164-10-3 4-amino-3-(6-phenylpyridine-3-ylazo)naphthalene-1-sulfonic acid sodium salt 
• 1357165-44-6 C₁₁H₈N₃⁽¹⁺⁾*Cl^(1-) 
• 1357166-19-8 2-(5-nitropyridine-2-yl)phenol 

Relevant articles and documents

Suzuki-Miyaura Cross-Couplings under Acidic Conditions

Suzuki-Miyaura reactions with Pd(PPh 3) 4 have been carried out using lithium N -phenylsydnone-4-carboxylate as additive, which gave best yields at pH 5.7 in a mixture of acetic acid, water, and sodium carbonate. Reaction parameters such as the Pd source, the solvent, reaction time and temperature, acid, base and carboxylate have been varied and some representative examples of the Suzuki-Miyaura reaction have been examined.

Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions

A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.

METHODS OF USING INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS

This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.