890839-70-0 Usage
General Description
8-(trifluoromethyl)chroman-4-amine is a chemical compound with the molecular formula C9H8F3NO. It is a derivative of chroman-4-amine, with a trifluoromethyl group attached to the eighth position of the chroman ring. 8-(trifluoromethyl)chroman-4-amine is of interest in medicinal chemistry due to its potential biological activities, including as a potential antiviral and anticancer agent. The trifluoromethyl group is known for enhancing the pharmacological properties of organic molecules, making 8-(trifluoromethyl)chroman-4-amine a promising candidate for drug development. Further research is needed to fully understand the potential applications of this compound in various fields of medicine and pharmacology.
Check Digit Verification of cas no
The CAS Registry Mumber 890839-70-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,8,3 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 890839-70:
(8*8)+(7*9)+(6*0)+(5*8)+(4*3)+(3*9)+(2*7)+(1*0)=220
220 % 10 = 0
So 890839-70-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H10F3NO/c11-10(12,13)7-3-1-2-6-8(14)4-5-15-9(6)7/h1-3,8H,4-5,14H2
890839-70-0Relevant articles and documents
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists
Schmidt, Robert G.,Bayburt, Erol K.,Latshaw, Steven P.,Koenig, John R.,Daanen, Jerome F.,McDonald, Heath A.,Bianchi, Bruce R.,Zhong, Chengmin,Joshi, Shailen,Honore, Prisca,Marsh, Kennan C.,Lee, Chih-Hung,Faltynek, Connie R.,Gomtsyan, Arthur
, p. 1338 - 1341 (2011/04/23)
Novel chroman and tetrahydroquinoline ureas were synthesized and evaluated for their activity as TRPV1 antagonists. It was found that aryl substituents on the 7- or 8-position of both bicyclic scaffolds imparted the best in vitro potency at TRPV1. The most potent chroman ureas were assessed in chronic and acute pain models, and compounds with the ability to cross the blood-brain barrier were shown to be highly efficacious. The tetrahydroquinoline ureas were found to be potent CYP3A4 inhibitors, but replacement of bulky substituents at the nitrogen atom of the tetrahydroisoquinoline moiety with small groups such as methyl can minimize the inhibition.