89152-86-3

Basic information

• Product Name: C-(2-P-TOLYL-THIAZOL-4-YL)-METHYLAMINE
• Synonyms: C-(2-P-TOLYL-THIAZOL-4-YL)-METHYLAMINE;(2-p-Tolyl-thiazol-4-yl)methylamine;[2-(4-Methylphenyl)-1,3-thiazol-4-yl]methylamine;[2-(4-methylphenyl)-1,3-thiazol-4-yl]methanamine;[2-(4-methylphenyl)-4-thiazolyl]methanamine;[2-(4-methylphenyl)thiazol-4-yl]methanamine;[2-(4-methylphenyl)thiazol-4-yl]methylamine;2-(4-methylphenyl)-4-Thiazolemethanamine
• CAS NO: 89152-86-3
• Molecular Formula: C11H12N2S
• Molecular Weight: 204.29
• Mol File: 89152-86-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: C-(2-P-TOLYL-THIAZOL-4-YL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(2-P-TOLYL-THIAZOL-4-YL)-METHYLAMINE(89152-86-3)
• EPA Substance Registry System: C-(2-P-TOLYL-THIAZOL-4-YL)-METHYLAMINE(89152-86-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 89152-86-3(Hazardous Substances Data)

Usage

General Description

C-(2-P-tolyl-thiazol-4-yl)-methylamine is a chemical compound that consists of a thiazole ring with a p-tolyl substituent attached at the 2-position, and a methylamine group attached at the 4-position. Thiazole is a five-membered heterocyclic compound containing both sulfur and nitrogen atoms, and is commonly found in various pharmaceuticals and agrochemicals due to its versatile biological activity. The p-tolyl group adds flexibility and steric hindrance to the molecule, which can impact its pharmacological properties. C-(2-P-tolyl-thiazol-4-yl)-methylamine may have potential applications in drug discovery and development, particularly as a building block for the synthesis of novel bioactive compounds. Further research is needed to fully understand the properties and potential uses of this chemical.

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Relevant articles and documents

Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optimal fungicidal activity, which respectively offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to commercial fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound T18 has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future.

N-heteroarylmethylpyrimidinamine compound, preparation method and applications thereof

The invention discloses an N-heteroarylmethylpyrimidinamine compound represented by a formula (I), a preparation method and applications thereof, wherein R, R, R, R, R, X and n in the formula (1) are defined in the specification. According to the present invention, the compound represented by the formula (I) has insecticidal/mite killing and/or bactericidal biological activity, and particularly provides high activity against Homoptera pests such as aphids, planthoppers and the like.

5-pyrazole amide compound, and preparation method and application thereof

The invention discloses a 5-pyrazole amide compound as shown in a formula (I) which is described in the specification, and a preparation method and application thereof. In the formula (I), R, R1, R2, R3 and n are as defined in the specification. The 5-pyrazole amide compound as shown in the formula (I) has bactericidal, insecticidal or acaricidal bioactivity and especially has good activity to insects like aphids belonging to Homoptera and pathogens like Sphaerotheca fuliginea, Botrytis cinerea and rust pathogens.