891842-50-5

Basic information

• Product Name: 2-Bromo-6-chloroquinoline
• Synonyms: 2-bromo-6-chloroquinoline
• CAS NO: 891842-50-5
• Molecular Formula: C₉H₅BrClN
• Molecular Weight: 242.5
• Mol File: 891842-50-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 328.087 °C at 760 mmHg
• Flash Point: 152.222 °C
• Appearance: /
• Density: 1.673
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.68
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.31±0.43(Predicted)
• CAS DataBase Reference: 2-Bromo-6-chloroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-chloroquinoline(891842-50-5)
• EPA Substance Registry System: 2-Bromo-6-chloroquinoline(891842-50-5)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 891842-50-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-6-chloroquinoline is a chemical compound that falls under the category of quinolines which are heterocyclic aromatic organic compounds. Its molecular formula is C9H5BrClN and it has a molecular weight of 246.5 g/mol. 2-Bromo-6-chloroquinoline is generally used in pharmaceutical chemistry due to its pharmacological properties. It is prominently utilized in the production of drugs, including antimalarial, antibacterial, and anti-inflammatory medications. Moreover, 2-Bromo-6-chloroquinoline is also seen in the production of dyes as it can readily bind to fabric and provide long-lasting color. It is noted, however, that like other quinoline derivatives, it should be handled with care due to potential toxicity.

InChI:InChI=1/C9H5BrClN/c10-9-4-1-6-5-7(11)2-3-8(6)12-9/h1-5H

Upstream product

• 1810-67-9 6-chloroquinolin-2(1H)-oney 
• 612-57-7 6-chloroquinoline 
• 6563-10-6 6-chloroquinoline N-oxide 

Downstream Products

• 1394231-88-9 N-(2-(tert-butyldiphenylsiloxy)ethyl)-6-(2-(6-chloroquinolin-2-yl)thiazol-4-yl)-5-methoxy-1-methyl-3-(methylthio)-4-oxo-1,4-dihydropyridine-2-carboxamide 
• 1416805-42-9 1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol 
• 1416805-61-2 1-(6-Chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(4H-1,2,4-triazol-4-yl)propan-2-ol 
• 1416805-30-5 1-(6-Chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol 
• 1416805-92-9 C₁₇H₈ClF₄NO 
• 1416805-93-0 C₁₈H₁₀ClF₄NO 
• 1416806-03-5 C₁₈H₁₃ClF₄N₂O 
• 60301-56-6 6-chloro-2-phenylquinoline 

Relevant articles and documents

A highly practical and convenient halogenation of fused heterocyclic N-oxides

A novel, simple and practical method for the regioselective halogenation of fused heterocyclic N-oxides has been developed. It employs Vilsmeier reagent, generated in situ by POX3and DMF, as both the activating agent and the nucleophilic halide source. The method is amenable across a broad range of substrates, including quinolines, isoquinolines and the diazine N-oxides, possessing a variety of substitution patterns. Furthermore, all of the reagents associated are cheap and easy to obtain. The potential extension of this method to a one-pot oxidation/halogenation sequence that obviates the need for isolation of the N-oxide intermediates is also presented.

Heterocyclic compounds as inhibitors of factor VIIa

The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable salt, solvate, or prodrug form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.