89245-41-0

Basic information

• Product Name: 1H-Indole-3-aceticacid,4-bromo-(9CI)
• Synonyms: 1H-Indole-3-aceticacid,4-bromo-(9CI);2-(4-bromo-1H-indol-3-yl)acetic acid;1H-Indole-3-acetic acid, 4-broMo-;4-broMo-1H-indole-3-acetic acid;4-Bromo-3-indoleacetic acid;(4-Bromo-1H-indol-3-yl)-acetic acid
• CAS NO: 89245-41-0
• Molecular Formula: C₁₀H₈BrNO₂
• Molecular Weight: 254.09
• Product Categories: INDOLE
• Mol File: 89245-41-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 185-187℃ (DEC.)
• Appearance: /
• Density: 1.746
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Indole-3-aceticacid,4-bromo-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-aceticacid,4-bromo-(9CI)(89245-41-0)
• EPA Substance Registry System: 1H-Indole-3-aceticacid,4-bromo-(9CI)(89245-41-0)

Safety Data

• Hazardous Substances Data: 89245-41-0(Hazardous Substances Data)

Usage

General Description

1H-Indole-3-aceticacid,4-bromo-(9CI) is a chemical compound that belongs to the class of indoleacetic acids, which are known for their plant hormone activity. Its molecular formula is C10H8BrNO2 and it has a molar mass of 268.08 g/mol. 1H-Indole-3-aceticacid,4-bromo-(9CI) contains a bromine atom and a carboxylic acid group attached to an indole ring. The presence of the bromine atom makes it particularly useful in biochemical and pharmaceutical research. It has the potential to be used in the development of new plant growth regulators or as a starting material for the synthesis of other biologically active compounds. Additionally, it may have applications in the field of medicine and can potentially be used as a pharmaceutical intermediate in drug discovery and development.

Upstream product

• 89245-35-2 2-(4-bromo-1H-indol-3-yl)acetonitrile 
• 89434-01-5 4-bromo-1-methoxycarbonyl-3-indoleacetonitrile 
• 52488-36-5 4-bromo-1H-indole 
• 4769-97-5 4-nitro-1H-indoIe 
• 942-24-5 3-methoxycarbonylindole 
• 64258-88-4 1-(4-bromo-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 4770-06-3 4-nitroindole-3-acetonitrile 
• 7150-46-1 4-nitrogramine 
• 89245-39-6 4-amino-1-methoxycarbonyl-3-indoleacetonitrile 
• 89245-40-9 1-methoxycarbonyl-4-nitro-3-indoleacetonitrile 
• 101909-45-9 4-bromo-1-methoxycarbonylindole 
• 101909-43-7 4-bromo-1H-indole-3-carboxylic acid methyl ester 
• 65018-18-0 1,3-diacetyl-4-bromoindole 

Downstream Products

• 89245-37-4 methyl (4-bromo-1H-indole-3-yl)acetate 
• 1273005-81-4 S-ethyl 2-(4-bromo-1-tosyl-1H-indol-3-yl)ethanethioate 
• 1273005-95-0 1-(4-bromo-1-tosyl-1H-indol-3-yl)-4-[(2R,5S)-2-phenyl-3-tosyl-1,3-oxazinan-5-yl]but-3-yn-2-one 
• 1273006-07-7 (R)-1-(4-bromo-1-tosyl-1H-indol-3-yl)-4-[(2R,5S)-2-phenyl-3-tosyl-1,3-oxazinan-5-yl]but-3-yn-2-ol 
• 1273006-13-5 (S)-1-(4-bromo-1-tosyl-1H-indol-3-yl)-4-[(2R,5S)-2-phenyl-3-tosyl-1,3-oxazinan-5-yl]but-3-yn-2-ol 
• 202753-56-8 2-(1H-4-bromoindol-3-yl)-ethanol 
• 1370699-77-6 4-bromoindole-3-acetaldehyde 

Relevant articles and documents

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst

Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.

Enantioselective total synthesis of (+)-lysergic acid, (+)-lysergol, and (+)-isolysergol by palladium-catalyzed domino cyclization of allenes bearing amino and bromoindolyl groups

Enantioselective total synthesis of the biologically important indole alkaloids (+)-lysergol, (+)-isolysergol, and (+)-lysergic acid is described. Key features of these total synthesis include (1) a facile synthesis of a chiral 1,3-amino alcohol via the Pd(0)- and In(I)-mediated reductive coupling reaction between l-serine-derived 2-ethynylaziridine and formaldehyde; (2) the Cr(II)/Ni(0)-mediated Nozaki-Hiyama-Kishi (NHK) reaction of an indole-3-acetaldehyde with iodoalkyne; and (3) Pd(0)-catalyzed domino cyclization of an allene bearing amino and bromoindolyl groups. This domino cyclization enabled direct construction of the C/D ring system of the ergot alkaloids skeleton, as well as the creation of the C5 stereogenic center with transfer of the allenic axial chirality to the central chirality.