89265-35-0

Basic information

• Product Name: 2-(METHYLSULFONYL)BENZENESULFONYL CHLORIDE
• Synonyms: o-Chlorosulfonylphenyl methyl sulfone.;2-Methysulfonylbenzenesulfonyl chloride;2-(Methylsulfonyl)benzenesulfonyl chloride,95%;2-(Methylsulphonyl)benzenesulphonyl chloride 95%;2-(Chlorosulphonyl)phenyl methyl sulphone;2-(Methylsulfonyl)benzenesulfonyl chloride, 95% 2.5GR;2-(Methylsulphonyl)benzenesulphonylchloride95%;2-(Methylsulfonyl)benzene-1-sulfonyl chloride
• CAS NO: 89265-35-0
• Molecular Formula: C₇H₇ClO₄S₂
• Molecular Weight: 254.71
• Product Categories: Benzenesulfonyl chloride
• Mol File: 89265-35-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 133-138 °C
• Boiling Point: 442 °C at 760 mmHg
• Flash Point: 221.1 °C
• Appearance: Off-white to yellow-brown/Crystalline Powder
• Density: 1.4936 (estimate)
• Vapor Pressure: 1.35E-07mmHg at 25°C
• Refractive Index: 1.554
• Water Solubility: Reacts with water.
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2-(METHYLSULFONYL)BENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLSULFONYL)BENZENESULFONYL CHLORIDE(89265-35-0)
• EPA Substance Registry System: 2-(METHYLSULFONYL)BENZENESULFONYL CHLORIDE(89265-35-0)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38-34
• Safety Statements: 37/39-26-45-36/37/39
• RIDADR: UN3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 89265-35-0(Hazardous Substances Data)

Usage

Chemical Properties

off-white to yellowish-brown crystalline powder

InChI:InChI=1/C7H7ClO4S2/c1-13(9,10)6-4-2-3-5-7(6)14(8,11)12/h2-5H,1H3

Upstream product

• 99862-30-3 1-butylsulfanyl-2-methylsulfanyl-benzene 
• 282719-68-0 benzyl o-methylsulfonylphenyl sulfide 
• 2987-49-7 2-(methylsulfonyl)aniline 
• 17482-05-2 o-chlorophenyl methyl sulfone 
• 17733-22-1 2-chlorothioanisole 
• 60036-47-7 o-methylsulphonylphenyl methyl sulphide 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 197960-66-0 3-hydroxy-5-methylphenyl 2-(methylsulfonyl)benzenesulfonate 
• 3112-85-4 methylphenylsulfonate 
• 125106-55-0 o-mercaptophenyl methyl sulfone 
• 1000303-54-7 4-((3S,4S)-3-(tert-butoxycarbonylamino)-4-(2-oxopiperidin-1-yl)pyrrolidin-1-yl)quinazolin-7-yl 2-(methylsulfonyl)benzenesulfonate 
• 1000303-58-1 C₂₉H₃₃F₂N₅O₈S₂ 
• 86411-16-7 2-(Methylsulfonyl)phenyl disulfide 
• 599183-11-6 2-methylsulfonyl-N-(3-phenyl-1H-indazol-5-yl)benzenesulfonamide 
• 1348323-83-0 N-[3-(4-Methoxyphenyl)-1H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide 
• 1279871-80-5 N-(3-bromo-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide 
• 599183-05-8 N-(3-chloro-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide 
• 599183-09-2 N-(3-cyano-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide 
• 599183-34-3 N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide 
• 599183-22-9 N-phenyl-5-(2-methylsulfonylbenzenesulfonylamino)-1H-indazole-3-carboxamide 

Relevant articles and documents

Development of the large-scale preparation of 2-(Methanesulfonyl) benzenesulfonyl chloride

A practical and scalable process is described for the preparation of 2-(methansulfonyl)benzenesulfonyl chloride, a key building block used in the synthesis of several drug candidates. The material is prepared by an efficient four-step sequence from inexpe

Process for the preparation of 2-[alkyl(aryl)]sulfonylbenzene-sulfonyl chlorides and their intermediates

A process for the preparation of 2-[alkyl(aryl)]sulfonylbenzene sulfonyl chlorides of the following formula is provided: in which R is alkyl or aryl substituted at the ortho or meta positions with alkyl, aryl, NHAc or alkoxy, comprising the steps of: a) r