89277-99-6

Basic information

• Product Name: (2-CHLORO-4-NITROPHENYL)-ACETONITRILE
• Synonyms: 2-(2-CHLORO-4-NITROPHENYL)ACETONITRILE;(2-CHLORO-4-NITROPHENYL)-ACETONITRILE
• CAS NO: 89277-99-6
• Molecular Formula: C₈H₅ClN₂O₂
• Molecular Weight: 196.59
• Mol File: 89277-99-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 352.4°C at 760 mmHg
• Flash Point: 166.9°C
• Appearance: /
• Density: 1.409g/cm³
• Vapor Pressure: 3.85E-05mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: (2-CHLORO-4-NITROPHENYL)-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-4-NITROPHENYL)-ACETONITRILE(89277-99-6)
• EPA Substance Registry System: (2-CHLORO-4-NITROPHENYL)-ACETONITRILE(89277-99-6)

Safety Data

• Hazardous Substances Data: 89277-99-6(Hazardous Substances Data)

Usage

General Description

(2-Chloro-4-nitrophenyl)-acetonitrile is a chemical compound with the molecular formula C8H5ClN2O2. It is a nitrophenyl acetonitrile derivative, which is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. This chemical is known for its potential use as a building block in the production of drugs and other fine chemicals. It is characterized by its yellow crystalline appearance and is soluble in most organic solvents. Additionally, it is important to handle this compound with care, as it may be harmful if swallowed, inhaled, or comes into contact with the skin.

InChI:InChI=1/C8H5ClN2O2/c9-8-5-7(11(12)13)2-1-6(8)3-4-10/h1-2,5H,3H2

Upstream product

• 121-73-3 3-Nitrochlorobenzene 
• 5219-61-4 (phenylthio)acetonitrile 
• 107-14-2 chloroacetonitrile 
• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 121-86-8 2-chloro-4-nitrotoluene 

Downstream Products

• 848133-05-1 2-(4-amino-2-chlorophenyl)ethanethioamide 
• 952202-60-7 (Z)-2-(2-chloro-4-nitro-phenyl)-3-dimethylaminoacrylonitrile 
• 848133-57-3 6-amino-4-[3-chloro-4-(4-phenyl-thiazol-2-ylmethyl)-phenylamino]-7-methoxy-quinoline-3-carbonitrile 
• 609347-36-6 3-chloro-4-(1-methyl-1H-imidazol-2-ylmethyl)-phenylamine 
• 609347-34-4 2-(2-chloro-4-nitro-benzyl)-1H-imidazole 
• 609347-35-5 2-(2-chloro-4-nitro-benzyl)-1-methyl-1H-imidazole 
• 180150-18-9 (4-amino-2-chloro-phenyl)-acetonitrile 
• 952202-58-3 (Z)-2-chloro-N-[3-chloro-4-(1-cyano-2-dimethylaminovinyl)phenyl]-benzenesulfonamide 
• 952202-55-0 N-[4-(7-amino-3-chloromethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide 
• 952202-56-1 N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide 
• 952202-57-2 C₂₁H₁₇Cl₂N₅O₄S 

Relevant articles and documents

NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE

The present invention provides new compounds of formula I, wherein Q, R1, R2, R4, R5, R6, Xi, R7, R8, M and G1 nare defined as in formula I; invention compounds are modulators of follicle-stimulating hormone - ("FSH") which are useful for male and female contraception as well as other disorders modulated by FSH receptor.

Vicarious Nucleophilic Substitution of Hydrogen in Nitroarenes with α-Substituted Nitriles and Esters. Direct α-Cyanoalkylation and α-Carbalkoxyalkylation of Nitroarenes

Carbanions generated from alkanenitriles bearing α-chloro, α-OR, or α-SR groups and from aliphatic esters bearing α-SR groups react with mononitroarenes to replace hydrogen atoms of the nitroaromatic ring ortho or para to the nitro group with α-cyanoalkyl or α-carbalkoxyalkyl substituents.The nucleophilic replacement of hydrogen with such carbanions proceeds faster than substitution of halogen ortho or para to the nitro group.