896100-50-8

Basic information

• Product Name: (S)-7-benzyl 1-tert-butyl 2-(tert-butoxycarbonyl)-5-oxoheptanedioate
• Synonyms: (S)-7-benzyl 1-tert-butyl 2-(tert-butoxycarbonyl)-5-oxoheptanedioate
• CAS NO: 896100-50-8
• Molecular Weight: 435.518
• Mol File: 896100-50-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-7-benzyl 1-tert-butyl 2-(tert-butoxycarbonyl)-5-oxoheptanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-7-benzyl 1-tert-butyl 2-(tert-butoxycarbonyl)-5-oxoheptanedioate(896100-50-8)
• EPA Substance Registry System: (S)-7-benzyl 1-tert-butyl 2-(tert-butoxycarbonyl)-5-oxoheptanedioate(896100-50-8)

Safety Data

• Hazardous Substances Data: 896100-50-8(Hazardous Substances Data)

Upstream product

• 35418-16-7 L-t-butyl pyroglutamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 540-88-5 acetic acid tert-butyl ester 
• 140-11-4 Benzyl acetate 
• 91229-91-3 tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate 

Relevant articles and documents

Substrate-dependent dihydroxylation of substituted cyclopentenes: Toward the syntheses of carbocyclic sinefungin and noraristeromycin

Carbocyclic nucleosides are of considerable interest for the development of new therapeutic agents. A key reaction in the preparation of many such nucleoside analogues is dihydroxylation of appropriately substituted cyclopentenes. Although often considered a routine reaction, in this paper, we report the dramatic influence of substituents on the facial selectivity of dihydroxylations. The substituted cyclopentene substrates are derived from acylnitroso cycloaddition reactions of cyclopentadiene, followed by N-O reduction and efficient enzymatic resolution. The results are directly utilized in a very efficient asymmetric synthesis of an antiviral carbocyclic nucleoside, noraristeromycin 5. Extensions toward the synthesis of carbocyclic sinefungin 7 document the importance of realizing the substituent dependence of the dihydroxylation reaction.