896134-06-8

Basic information

• Product Name: Donepezil Impurity
• Synonyms: 2,3-Dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methylene]-1H-inden-1-one;4-((5,6-dimethoxy-1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)pyridine 1-oxide;Donepezil Impurity P
• CAS NO: 896134-06-8
• Molecular Formula: C24H29NO3
• Molecular Weight: 379.49196
• Mol File: 896134-06-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 595.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 0.95±0.10(Predicted)
• CAS DataBase Reference: Donepezil Impurity(CAS DataBase Reference)
• NIST Chemistry Reference: Donepezil Impurity(896134-06-8)
• EPA Substance Registry System: Donepezil Impurity(896134-06-8)

Safety Data

• Hazardous Substances Data: 896134-06-8(Hazardous Substances Data)

Usage

General Description

Donepezil impurity is a chemical substance that is a byproduct of the production of the medication donepezil, which is commonly used to treat the symptoms of Alzheimer's disease. This impurity is a potential concern because it can affect the purity and efficacy of the final product, and may also pose a risk to patient safety if it is present in high enough quantities. Therefore, it is important for manufacturers and regulatory agencies to closely monitor and control the levels of donepezil impurity in pharmaceutical products to ensure their quality and safety for patients.

Upstream product

• 877606-65-0 (E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one 
• 872-85-5 pyridine-4-carbaldehyde 
• 2107-69-9 5,6-dimethoxy-1-indanone 

Downstream Products

• 1326306-15-3 5,6-dimethoxy-2-[1-(thioxo(2-toluidino)methyl)-4-piperidylmethyl]-1-indanone 
• 1326306-16-4 5,6-dimethoxy-2-[1-(thioxo(3-toluidino)methyl)-4-piperidylmethyl]-1-indanone 

Relevant articles and documents

Synthesis of new piperidyl indanone derivatives as anticonvulsant agents

A series of 5,6-dimethoxy-2-{1-[arylamino/ alkylamino(thioxo)methyl]-4- piperidyl-methyl}-1-indanones (4a-l) were designed and synthesized by the reaction of 5,6-dimethoxy-2-(piperidin-4-yl-methyl)-indan-1-one with aryl/ alkyl isothiocyanates. The anticonvulsant activity was evaluated in animal models by maximal electroshock seizure and subcutaneous pentylenetetrazole tests. The neurotoxic effects were assessed by rotorod and ethanol potentiation tests. Gamma amino butyric acid (GABA) estimation of the selected compounds was performed in rat brain utilizing UV absorbance data. Compounds 4d, 4g, and 4j displayed encouraging anticonvulsant profile against both seizure models with remarkably lower neurotoxicity. These compounds were found to increase the GABA level in rat brain significantly. Springer Science+Business Media, LLC 2011.