89638-21-1

Basic information

• Product Name: 2-Propen-1-one, 1-(2-fluorophenyl)-
• CAS NO: 89638-21-1
• Molecular Formula: C9H7FO
• Molecular Weight: 150.152
• Mol File: 89638-21-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-fluorophenyl)-(89638-21-1)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-fluorophenyl)-(89638-21-1)

Safety Data

• Hazardous Substances Data: 89638-21-1(Hazardous Substances Data)

Upstream product

• 58824-51-4 1-(2-fluorophenyl)-2-propen-1-ol 
• 898767-04-9 3-chloro-1-(2-fluorophenyl)propan-1-one 
• 127-19-5 N,N-dimethyl acetamide 
• 445-27-2 2'-Fluoroacetophenone 
• 198967-24-7 2-fluoro-N-methoxy-N-methyl-benzamide 
• 1826-67-1 vinyl magnesium bromide 

Downstream Products

• 123184-10-1 1-(2-Fluoro-phenyl)-5-methyl-hexane-1,4-dione 
• 1188930-90-6 C₁₅H₁₉NO 
• 1188930-87-1 C₁₇H₁₇NO 
• 1188930-91-7 3-(tert-butylamino)-1-(2-fluorophenyl)-1-propanone 
• 1188930-92-8 1-(2-fluorophenyl)-3-(phenylamino)-1-propanone 
• 3954-48-1 1-benzyl-2,3-dihydroquinolin-4(1H)-one 
• 1114086-12-2 (S)-3-(1-(4-bromophenyl)-ethylamino)-1-(2-fluorophenyl)-propan-1-one 
• 123185-41-1 (4R,6R)-6-{2-[2-(2-Fluoro-phenyl)-5-isopropyl-pyrrol-1-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one 
• 123184-42-9 3-[2-(2-Fluoro-phenyl)-5-isopropyl-pyrrol-1-yl]-propionitrile 
• 123184-77-0 3-[2-(2-Fluoro-phenyl)-5-isopropyl-pyrrol-1-yl]-propionaldehyde 
• 89638-41-5 2,2,2-Trichloro-N-[2-cyano-6-(2-fluoro-benzoyl)-3,4-dimethyl-phenyl]-acetamide 
• 89638-49-3 2-Bromo-N-[2-cyano-6-(2-fluoro-benzoyl)-3,4-dimethyl-phenyl]-acetamide 
• 89638-53-9 5-(2-Fluoro-phenyl)-7,8-dimethyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepine-9-carbonitrile 
• 89638-45-9 4-(2-Fluoro-phenyl)-6,7-dimethyl-2-oxo-1,2-dihydro-quinazoline-8-carbonitrile 

Relevant articles and documents

Stereodivergent Desymmetrization of Simple Dicarboxylates via Branch-Selective Pd/Cu Catalyzed Allylic Substitution

Asymmetric desymmetrization has been demonstrated to be a powerful strategy for building stereocenters in asymmetric synthesis. Herein, a Pd/Cu catalyzed asymmetric desymmetrization reaction with a simple geminal dicarboxylate is reported. A wide scope of imino esters bearing an aryl or heteroaromatic group were compatible with this bimetallic catalytic system. The reactions proceeded smoothly, giving the desired products in good yields with high to excellent regio-, diastereo-, and enantioselectivity (up to 20 : 1 branched:linear, >20 : 1 dr, >99 % ee). Notably, the reaction favored branched selectivity, which is unusual for the Pd-catalyzed allylic alkylation reaction. In addition, the standard product could be easily transformed to other valuable molecules such as chiral allylic alcohols, carbamates, and organic boron compounds. Furthermore, DFT calculations were conducted to explain the origin of the branched selectivity.

CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.