896464-16-7

Basic information

• Product Name: tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate
• Synonyms: tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate;2,7-Diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester;2,7-Diazaspiro[3.5]nonane-7-carboxylic acid 1,1-dimethylethyl ester;2,7-Diazaspiro[3.5]nonane-7-carboxylicacid, 1,1-diMethylethyl ester dihydrochloride;tert-butyl 2,7-diazaspiro(3,5)nonane-7-carboxylate hcl;2,7-Diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester hydrochloride;tert-Butyl 2,7-diazaspiro[3.5]none-7-carboxylate
• CAS NO: 896464-16-7
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 226.32
• Product Categories: Heterocycles series
• Mol File: 896464-16-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 319 °C
• Flash Point: 147 °C
• Appearance: /
• Density: 1.08
• Vapor Pressure: 2.76E-05mmHg at 25°C
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.68±0.20(Predicted)
• CAS DataBase Reference: tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate(896464-16-7)
• EPA Substance Registry System: tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate(896464-16-7)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 896464-16-7(Hazardous Substances Data)

Usage

Description

tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate is a chemical compound that serves as a reagent in the synthesis of various pharmaceutical agents, particularly in the development of kinase inhibitors.
Used in Pharmaceutical Industry:
tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate is used as a reagent for the synthesis of RET kinase inhibitors for the treatment of various cancers by targeting the RET protein, which is implicated in tumor growth and progression.
Additionally, it is used as a reagent in the preparation of CDK4/6 inhibitors, which are important in the regulation of cell cycle progression and have potential applications in cancer therapy by inhibiting the growth of cancer cells.

InChI:InChI=1/C12H22N2O2.ClH/c1-11(2,3)16-10(15)14-8-12(9-14)4-6-13-7-5-12;/h13H,4-9H2,1-3H3;1H

Downstream Products

• 1620515-65-2 2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol 
• 1620516-12-2 tert-butyl 2-(5-(2,3-difluoro-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate 
• 1620516-11-1 tert-butyl 2-(5-(2,3-difluoro-4-(((trifluoromethyl)sulfonyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate