897018-39-2Relevant articles and documents
Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid lamellarin D
Pla, Daniel,Marchal, Antonio,Olsen, Christian A.,Francesch, Andres,Cuevas, Carmen,Albericio, Fernando,Alvarez, Mercedes
, p. 3257 - 3268 (2007/10/03)
The marine alkaloid, Lamellarin D (Lam-D), has shown potent cytotoxicity in numerous cancer cell lines and was recently identified as a potent topoisomerase I inhibitor. A library of open lactone analogues of Lam-D was prepared from a methyl 5,6-dihydropy