897661-90-4

Basic information

• Product Name: 6-(4-chlorophenyl)-2H-phthalazin-1-one
• Synonyms: 6-(4-chlorophenyl)-2H-phthalazin-1-one
• CAS NO: 897661-90-4
• Molecular Weight: 256.691
• Mol File: 897661-90-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(4-chlorophenyl)-2H-phthalazin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-chlorophenyl)-2H-phthalazin-1-one(897661-90-4)
• EPA Substance Registry System: 6-(4-chlorophenyl)-2H-phthalazin-1-one(897661-90-4)

Safety Data

• Hazardous Substances Data: 897661-90-4(Hazardous Substances Data)

Upstream product

• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 573675-39-5 5-bromo-3-hydroxyisoindoline-1-one 
• 75884-70-7 6-bromophthalazin-1(2H)-one 
• 1679-18-1 4-Chlorophenylboronic acid 

Relevant articles and documents

A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties

Melanin-concentrating hormone receptor antagonists containing thieno- and a benzopyridazinone cores were designed and tested as potential anorectic agents. These ligands showed high affinity for the receptor, potent functional activity in vitro, and good oral bioavailability in rats. The thiophene analogue exhibited low iv clearance, long half-life, and high brain penetration. In obese rats, the thienopyridazinone demonstrated a dose-dependent reduction in feeding and body weight with doses between 1 and 10 mg kg-1.