897943-02-1

Basic information

• Product Name: (1S,2R,10aS)-2-benzyloxy-1-hydroxy-1,5,10,10a-tetrahydro-2H-pyrrolo[1,2-b]isoquinolin-3-one
• Synonyms: (1S,2R,10aS)-2-benzyloxy-1-hydroxy-1,5,10,10a-tetrahydro-2H-pyrrolo[1,2-b]isoquinolin-3-one
• CAS NO: 897943-02-1
• Molecular Weight: 309.365
• Mol File: 897943-02-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2R,10aS)-2-benzyloxy-1-hydroxy-1,5,10,10a-tetrahydro-2H-pyrrolo[1,2-b]isoquinolin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R,10aS)-2-benzyloxy-1-hydroxy-1,5,10,10a-tetrahydro-2H-pyrrolo[1,2-b]isoquinolin-3-one(897943-02-1)
• EPA Substance Registry System: (1S,2R,10aS)-2-benzyloxy-1-hydroxy-1,5,10,10a-tetrahydro-2H-pyrrolo[1,2-b]isoquinolin-3-one(897943-02-1)

Safety Data

• Hazardous Substances Data: 897943-02-1(Hazardous Substances Data)

Upstream product

• 170487-22-6 isoquinoline-3-carboxaldehyde ethylene glycol ketal 
• 897942-95-9 phenyl (2R,3R)-2-benzyloxy-3-hydroxy-3-(2-oxyisoquinolin-3-yl)propionate 
• 5470-80-4 3-formylisoquinoline 
• 897942-84-6 2-oxyisoquinoline-3-carbaldehyde 
• 897943-17-8 3-[1,3]dioxolan-2-ylisoquinoline 2-oxide 

Relevant articles and documents

Bis(oxazoline) lewis acid catalyzed aldol reactions of pyridine N-oxide aldehydes-synthesis of optically active 2-(1-hydroxyalkyl)pyridine derivatives: Development, scope, and total synthesis of an indolizine alkaloid

A new. short, and simplified procedure for the synthesis of optically active pyridine derivatives from prochiral pyridine-N-oxides is presented. The catalytic and asymmetric Mukaiyama aldol reaction between ketene silyl acetals and l-oxypyridine-2-carhaldehyde derivatives catalyzed by chiral copper(ii)-bis(oxazoline) complexes gave optically active 2-(hydroxyalkyl)-and 2-(anti-1.2-dihydroxyalkyl)pyridine derivatives in good yields and diastereoselectivities, and in excellent enantioselectivities - up to 99% enantiomeric excess. As a synthetic application of the developed method, a full account for the asymmetric total synthesis of a nonnatural indolizine alkaloid is provided.