89937-77-9

Basic information

• Product Name: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
• Synonyms: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate;Methyl 2-hydroxypyridine-4-carboxylate;Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate 98%;4-Pyridinecarboxylicacid,1,2-dihydro-2-oxo-,methylester(9CI);Methyl 2-oxo-1,2-dihydropyridine-4-carboxylate;Methyl 2-hydroxypyridine-...;Methyl 2-hydroxypyridine-4-carboxylate, 1,2-Dihydro-4-(methoxycarbonyl)-2-oxopyridine;Methyl1,2-dihydro-2-oxopyridine-4-carboxylate98%
• CAS NO: 89937-77-9
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.13538
• Product Categories: CARBOXYLICESTER;blocks;Pyridines;Heterocycle-Pyridine series
• Mol File: 89937-77-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 211-212 °C
• Boiling Point: 342.4 °C at 760 mmHg
• Flash Point: 160.9 °C
• Appearance: /
• Density: 1.263g/cm³
• Vapor Pressure: 7.53E-05mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 11.02±0.10(Predicted)
• CAS DataBase Reference: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate(89937-77-9)
• EPA Substance Registry System: Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate(89937-77-9)

Safety Data

• Hazard Codes: Xi
• RIDADR: UN2811
• Hazardous Substances Data: 89937-77-9(Hazardous Substances Data)

Usage

General Description

Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is an organic, aromatic compound classified under pyridones. It is also known with the systematic name 4Methoxycarbonyl-1,2-dihydropyridin-2-one. With a molecular formula of C8H9NO3, it contains carbon, hydrogen, nitrogen and oxygen atoms. This chemical plays a crucial role as an intermediate used in the synthesis of pharmaceuticals and agrochemicals. The substance is typically a liquid ranging from clear to light yellow in color. Although it is not widely studied, one should still follow safe handling protocols while using it.

InChI:InChI=1/C7H7NO3/c1-11-7(10)5-2-3-8-6(9)4-5/h2-4H,1H3,(H,8,9)

Upstream product

• 67-56-1 methanol 
• 22282-72-0 2-hydroxyisonicotinic acid 
• 3783-38-8 methyl isonicotinate N-oxide 
• 6313-54-8 2-chloroisonicotinic acid, 
• 13362-28-2 2-aminoisonicotinic acid 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 22282-72-0 2-oxo-1,2-dihydropyridine-4-carboxylic acid 
• 105596-63-2 2-methoxy-isonicotinic acid 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 1160938-15-7 methyl 2-(acetyloxy)-4-pyridinecarboxylate 

Downstream Products

• 98140-91-1 2-hydroxy-isonicotinic acid hydrazide 
• 127838-58-8 4-(hydroxymethyl)pyridin-2(1H)-one 
• 127838-58-8 4-hydroxymethylpyridin-2-ol 
• 105590-03-2 4-chloromethyl-pyridin-2-ol 
• 918299-71-5 {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester 
• 504-29-0 2-aminopyridine 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 1072880-94-4 2-cyclohexylcarbamoyloxy-isonicotinic acid methyl ester 
• 1159599-62-8 2-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-isonicotinic acid methyl ester 
• 1245425-94-8 methyl 1-(4-methoxy-3-methylphenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 1245425-86-8 methyl 1-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 1256385-28-0 1-(4-ethoxycarbonylphenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid, triethylammonium salt 
• 1354355-99-9 methyl 1-(3-fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 1354356-02-7 methyl 1-(3-fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid 

Relevant articles and documents

Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs

In previous study, a series of benzamides was identified as potent antipsychotic agents. As a continuation of the program to discover novel antipsychotics, herein we reported the evaluation of a series of pyridinecarboxamide derivatives. The most promising compound 7h not only held good activities on dopamine D2, serotonin 5-HT1A and 5-HT2A receptors, but also exhibited low potency for α1A, H1 and 5-HT2C receptors, indicating a low propensity of side effects like orthostatic hypotension and weight gain. Furthermore, 7h exhibited more potent antipsychotic-like effect than aripiprazole in behavioral studies. The preliminary results were promising enough for further research around this scaffold.

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Provided are quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, L, X 1, X 2, and X 3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.