899435-22-4

Basic information

• Product Name: 3'-tritylamino-2',3'-dideoxyadenosine
• Synonyms: 3'-tritylamino-2',3'-dideoxyadenosine
• CAS NO: 899435-22-4
• Molecular Weight: 492.58
• Mol File: 899435-22-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3'-tritylamino-2',3'-dideoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-tritylamino-2',3'-dideoxyadenosine(899435-22-4)
• EPA Substance Registry System: 3'-tritylamino-2',3'-dideoxyadenosine(899435-22-4)

Safety Data

• Hazardous Substances Data: 899435-22-4(Hazardous Substances Data)

Upstream product

• 125944-11-8 9-(3'-amino-2',3'-dideoxy-β-D-ribofuranosyl)adenine 
• 76-83-5 trityl chloride 

Downstream Products

• 1417713-27-9 C₃₅H₄₂N₆O₂Si 
• 195375-63-4 N-benzoyl-2 ^{FontWeight=Bold FontSize=10} ',3'-dideoxy-3'-[(triphenylmethyl)amino]adenosine 

Relevant articles and documents

Synthesis of all four nucleoside-based β-amino acids as protected precursors for the synthesis of polyamide-DNA with alternating α-amino acid and nucleoside-β-amino acids

A simple approach is described for the synthesis of all four orthogonally protected nucleoside-β-amino acids from commercially available starting materials. Synthesis of a model tetrameric DNA sequence in 5′-3'direction employing trityl strategy and glycine as α-amino acid alternating with nucleoside-β amino acids is described.

A new approach to oligonucleotide N3′ → P5′ phosphoramidate building blocks

A new synthetic approach to 5′-phosphoramidites of 3′-aminonucleosides was developed. The methodology relies upon the use of 3′-amino-2′,3′-dideoxynucleosides as the key starting materials. The final products were obtained in high yields via 2-3-step processes using selective introduction of orthogonal protective groups to the 3′-aminonucleoside sugar and base moieties.