899435-27-9Relevant articles and documents
A new approach to oligonucleotide N3′ → P5′ phosphoramidate building blocks
Zielinska, Daria,Pongracz, Krisztina,Gryaznov, Sergei M.
, p. 4495 - 4499 (2006)
A new synthetic approach to 5′-phosphoramidites of 3′-aminonucleosides was developed. The methodology relies upon the use of 3′-amino-2′,3′-dideoxynucleosides as the key starting materials. The final products were obtained in high yields via 2-3-step processes using selective introduction of orthogonal protective groups to the 3′-aminonucleoside sugar and base moieties.