89979-04-4

Basic information

• Product Name: Benzenemethanol, 4-chloro-a-(nitromethyl)-
• CAS NO: 89979-04-4
• Molecular Formula: C8H8ClNO3
• Molecular Weight: 201.609
• Mol File: 89979-04-4.mol
• Article Data: 109

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-chloro-a-(nitromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-chloro-a-(nitromethyl)-(89979-04-4)
• EPA Substance Registry System: Benzenemethanol, 4-chloro-a-(nitromethyl)-(89979-04-4)

Safety Data

• Hazardous Substances Data: 89979-04-4(Hazardous Substances Data)

Usage

Structure

Consists of a benzene ring with a chloro substituent at the 4-position and a nitromethyl group attached to the alpha carbon

Uses

Building block in organic synthesis, pharmaceutical manufacturing, production of pesticides and agricultural chemicals

Safety precautions

Considered harmful if swallowed, inhaled, or comes into contact with skin

Upstream product

• 563-70-2 bromonitromethane 
• 104-88-1 4-chlorobenzaldehyde 
• 5468-33-7 1-(4-chlorophenyl)-2-nitroethan-1-one 
• 74-11-3 para-chlorobenzoic acid 
• 10364-95-1 1-(4-chloro-benzoyl)-1H-imidazole 
• 75-52-5 nitromethane 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 
• 60947-43-5 1-chloro-4-(2-nitroethyl)benzene 
• 41870-82-0 2-amino-1-(4-chlorophenyl)ethanol 
• 63701-56-4 (+)-Baclofen hydrochloride 

Relevant articles and documents

Revisit to Henry reaction by non conventional heterogeneous and efficient catalyst for nitroalcohol synthesis

A sustainable, green and efficient process for the synthesis of 2-nitro alcohol derivatives from different substituted aromatic aldehydes with nitroalkane by stirring at ambient temperature with high product yield is reported. Adoption of very mild reaction conditions, use of Calcined Eggshell (CES) as natural catalyst and simple workup are expected to contribute to the development of environmentally benign synthetic method for Henry (nitroaldol) reaction. CES is ecologically safe, inexpensive, and attractive heterogeneous base catalyst obtained from renewable resources, thus opening a new perspective for this process. Graphical abstract: [Figure not available: see fulltext.]

Method for preparing 2-nitroalkyl-1-alcohol compound and application thereof

The invention relates to a method for preparing a 2-nitroalkane-1-alcohol compound and application thereof, and particularly provides a method for preparing the 2-nitroalkane-1-alcohol compound from iron powder/lead dichloride. The process has the advantages of good yield, high diastereoselectivity, wide functional group tolerance and good compatibility.

Efficient Synthesis of α-Ketothioamides From α-Nitroketones, Amines or DMF and Elemental Sulfur Under Oxidant-Free Conditions

We have developed a practical, general protocol for denitration of readily available α-nitroketones with sulfur and amines to access a broad range of α-ketothioamides under mild conditions. Such a reaction proceeds under metal-, oxidant-, and catalyst-free conditions to provide synthetically useful α-ketothioamides. Furthermore, the mild reaction conditions tolerate a wide range of substrates especially for the synthesis of aliphatic α-ketothioamides which are rarely reported.