899806-25-8

Basic information

• Product Name: 2-Chloro-6-fluorophenylisothiocyanate
• Synonyms: 2-Chloro-6-fluorophenylisothiocyanate;1-Chloro-3-fluoro-2-isothiocyanatobenzene;2-Chloro-6-Fluorophenyl isothiocyante
• CAS NO: 899806-25-8
• Molecular Formula: C₇H₃ClFNS
• Molecular Weight: 187.6218232
• Mol File: 899806-25-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 261℃
• Flash Point: 112℃
• Appearance: /
• Density: 1.31
• CAS DataBase Reference: 2-Chloro-6-fluorophenylisothiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-fluorophenylisothiocyanate(899806-25-8)
• EPA Substance Registry System: 2-Chloro-6-fluorophenylisothiocyanate(899806-25-8)

Safety Data

• Hazardous Substances Data: 899806-25-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-fluorophenylisothiocyanate is a chemical compound known for its use in research and development settings. 2-Chloro-6-fluorophenylisothiocyanate, which includes elements such as chloro, fluoro, and isothiocyanate groups attached to a benzene ring, is utilized in a variety of different chemical reactions. It's often employed in the synthesis of other chemical substances, like pharmaceutical drugs or specialty chemicals. However, due to its reactive nature and toxicity, it should be handled with extreme caution. Its physical and chemical properties, including its molecular weight, boiling point, and melting point, would vary depending on its specific formulation and the conditions under which it is stored or used.

Upstream product

• 363-51-9 2-chloro-6-fluoroaniline 
• 96989-50-3 di-2-pyridyl thionocarbonate 
• 463-71-8 thiophosgene 
• 59772-35-9 N-(2-chloro-6-fluorophenyl)thiourea 

Downstream Products

• 1374298-75-5 methyl 2-((2-chloro-6-fluorophenyl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate 
• 1362477-26-6 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine 
• 1449316-63-5 3-(2-bromo-4-fluorophenyl)-4-[(2-chloro-6-fluorophenyl)amino]-4-(methylthio)-3-buten-2-one 
• 1374298-40-4 methyl 2-[(2-chloro-6-fluorophenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate 
• 1374298-42-6 methyl 2-[(2-chloro-6-fluorophenyl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxylate 
• 1374296-42-0 2-((2-chloro-6-fluorophenyl)amino)-N-(4-fluorophenyl)-7-methyl-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374296-28-2 2-((2-chloro-6-fluorophenyl)amino)-N-(4-fluorophenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374297-02-5 2-((2-chloro-6-fluorophenyl)amino)-7,7-dimethyl-N-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 

Relevant articles and documents

Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1

This letter describes the synthesis and biological evaluation of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as novel mPGES-1 inhibitors, capable of inhibiting an increased PGE2 production in the disease state. Structure-activity optimization afforded many potent mPGES-1 inhibitors having 50 of 14.3 mg/kg in guinea pig.

FUNGICIDAL PYRAZOLE MIXTURES

Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, (1) wherein R1 is H or halogen; R2 is H or halogen; R3 is halogen; R4 is halogen or CH3; and R5 is halogen, cyano, CH3 or C1-C2 alkoxy; and (b) at least one additional fungicidal compound selected from those disclosed herein. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of the aforesaid composition.

TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as m PGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (m PGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.