9000-88-8

Basic information

• Product Name: D-AMINO ACID OXIDASE
• Synonyms: EC 1.4.3.3;D-AMINO ACID OXIDASE TV;D-AMINO ACID:OXYGEN OXIDOREDUCTASE;D-AMINO ACID : OXYGEN OXIDOREDUCTASE (DEAMINATING);D-AMINO ACID OXIDASE;D-AMINO ACID OXIDASE, CARRIER-FIXED;D-AMINO ACID OXIDASE, IMMOBILIZED;D-AAO
• CAS NO: 9000-88-8
• Molecular Formula: C9H20N2O2
• Molecular Weight: 0
• EINECS: 232-563-5
• Product Categories: Oxidoreductases;Specialty Enzymes
• Mol File: 9000-88-8.mol
• Article Data: 0

Chemical Properties

• Appearance: yellow/powder
• Storage Temp.: −20°C
• Merck: 13,413
• CAS DataBase Reference: D-AMINO ACID OXIDASE(CAS DataBase Reference)
• NIST Chemistry Reference: D-AMINO ACID OXIDASE(9000-88-8)
• EPA Substance Registry System: D-AMINO ACID OXIDASE(9000-88-8)

Safety Data

• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 9000-88-8(Hazardous Substances Data)

Usage

Description

D-AMINO ACID OXIDASE, also known as DAO, is an enzyme that plays a crucial role in the metabolism of D-amino acids. It is responsible for catalyzing the oxidation of D-amino acids to their corresponding imino acids, which are then hydrolyzed to the corresponding α-keto acids. This process is essential for maintaining the balance of D-amino acids in the body and has been linked to various physiological functions and potential therapeutic applications.
Used in Pharmaceutical Industry:
D-AMINO ACID OXIDASE is used as a target molecule for the development of drugs to treat chronic pain and schizophrenia. The modulation of DAO activity has been shown to have potential therapeutic effects in these conditions, making it a promising target for drug discovery and development.
Used in Neurological Applications:
D-AMINO ACID OXIDASE is used as a therapeutic agent for the treatment of neurological disorders, particularly schizophrenia. The enzyme has been found to play a role in the regulation of glutamatergic neurotransmission, which is implicated in the pathophysiology of schizophrenia. Modulating DAO activity can help restore the balance of D-serine, a co-agonist of NMDA receptors, and potentially alleviate symptoms of the disorder.
Used in Pain Management:
D-AMINO ACID OXIDASE is used as a pain management agent for the treatment of chronic pain. The enzyme has been shown to modulate the activity of the NMDA receptor, which is involved in pain perception and transmission. By targeting DAO, it may be possible to develop novel pain management therapies that are more effective and have fewer side effects compared to current treatments.