9005-65-6 Usage
Description
Tween 80, also known as polysorbate 80, is a synthetic compound that is widely applied in various fields, including foods, medicines, and cosmetics. It is a polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 and a single terminal is capped by an oleoyl group. Tween 80 has a faint, characteristic odor and a warm, somewhat bitter taste. It is a mixture of oleate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide for each mole of sorbitol and its monoand dianhydrides.
Uses
Used in Food Industry:
Tween 80 is used as an emulsifier in ice cream and puddings to maintain a creamy texture without separation. It also serves as a defoamer in the fermenting process of some wines.
Used in Pharmaceutical Industry:
Tween 80 is used as an excipient to stabilize aqueous formulations of medications for parenteral administration and to improve the consistency of gel capsules, making pills disperse easily in the stomach. It is also found in some vaccines, vitamins, and supplements.
Used in Cosmetics:
Tween 80 is used as a surfactant and solubilizer in the production of soaps and cosmetics, helping to dissolve ingredients and make products look creamier and more attractive.
Used in Laboratory:
Tween 80 is occasionally used for a test to identify the phenotype of a strain or isolate, such as mycobacteria, by splitting the compound into oleic acid and polyoxyethylated sorbitol.
Used in Cell Culture Media:
Tween 80 is used as an additive for cell culture media, increasing the transformation frequency of Brevibacterium lactofermentum and enhancing the secretion of acid and alkaline phosphatase by Neurospora crassa.
Used in Emulsification and Solubilization:
Tween 80 is used as an emulsifier in ice cream, whipped toppings, and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations.
Used in Plastics Industry:
Tween 80 is used as an antistat for PVC and as an antifog for PP, PE, PVC, and PS.
Used in Textile Chemicals, Household Products, and Cosmetic Formulations:
Tween 80 is a general-purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products, and cosmetic formulations (o/w emulsifier, viscosity modifier).
References
https://en.wikipedia.org/wiki/Polysorbate_80
http://thegoodhuman.com/what-is-polysorbate-80/
http://www.crodahealthcare.com/home.aspx?s=149&r=344&p=2259
https://pubchem.ncbi.nlm.nih.gov/compound/443315#section=Top
Characteristics
Tween 80, commercially known as Polysorbate-80, is a viscous, water-soluble Yellow to amber liquid derived from polyethoxylated sorbitan and oleic acid. Tween 80 is structurally similar to the (polyethylene) glycols and used both in injections (0.8-8.0%) and in oral suspension (0.375% w/v). A number of anticancer drugs can be formulated by Tween 80. Typical examples include etoposide and minor groove-binding cyclopropylpyrroloindole analogues like carzelesin.
Air & Water Reactions
Water soluble.
Reactivity Profile
Tween 80 is incompatible with strong alkalis and oxidizers.
Fire Hazard
Tween 80 is probably combustible.
Biochem/physiol Actions
Tween 80 is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.
Safety Profile
Moderately toxic by
intravenous route. Mildly toxic by ingestion.
Experimental reproductive effects.
Questionable carcinogen with experimental
tumorigenic data. Human mutation data
reported. An eye irritant. When heated to
decomposition it emits acrid smoke and
irritating fumes.
Check Digit Verification of cas no
The CAS Registry Mumber 9005-65-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 9005-65:
(6*9)+(5*0)+(4*0)+(3*5)+(2*6)+(1*5)=86
86 % 10 = 6
So 9005-65-6 is a valid CAS Registry Number.
InChI:InChI=1/C185H368O86/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-270-271-179-175-264-169-165-259-159-155-254-149-145-249-139-135-244-129-125-239-119-115-234-109-105-229-99-95-224-89-85-219-80-81-220-90-91-225-100-101-230-110-111-235-120-121-240-130-131-245-140-141-250-150-151-255-160-161-260-170-171-265-180-182(266-176-172-261-166-162-256-156-152-251-146-142-246-136-132-241-126-122-236-116-112-231-106-102-226-96-92-221-86-82-216-77-74-213-71-68-210-65-62-207-59-56-204-53-50-201-47-44-198-41-38-195-35-32-192-29-26-189-23-19-186)185-184(268-178-174-263-168-164-258-158-154-253-148-144-248-138-134-243-128-124-238-118-114-233-108-104-228-98-94-223-88-84-218-79-76-215-73-70-212-67-64-209-61-58-206-55-52-203-49-46-200-43-40-197-37-34-194-31-28-191-25-21-188)183(181-269-185)267-177-173-262-167-163-257-157-153-252-147-143-247-137-133-242-127-123-237-117-113-232-107-103-227-97-93-222-87-83-217-78-75-214-72-69-211-66-63-208-60-57-205-54-51-202-48-45-199-42-39-196-36-33-193-30-27-190-24-20-187/h9-10,182-188H,2-8,11-1
