9009-65-8

Basic information

• Product Name: PROTAMINE SULFATE
• Synonyms: angiociclan;dilangio;fluxema;Protamines,sulfates;usafd-4;vasorelax;CLUPEINE SULFATE;SALMINE
• CAS NO: 9009-65-8
• Molecular Formula: H2O4S
• Molecular Weight: 0
• EINECS: 232-726-0
• Mol File: 9009-65-8.mol
• Article Data: 0

Chemical Properties

• Appearance: white/amorphous powder
• Storage Temp.: +2C to +8C
• Solubility: H2O: 10 mg/mL
• Water Solubility: It is sparingly soluble in water.
• Sensitive: Hygroscopic
• CAS DataBase Reference: PROTAMINE SULFATE(CAS DataBase Reference)
• NIST Chemistry Reference: PROTAMINE SULFATE(9009-65-8)
• EPA Substance Registry System: PROTAMINE SULFATE(9009-65-8)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: VO9470000
• F: 21-10
• TSCA: Yes
• Hazardous Substances Data: 9009-65-8(Hazardous Substances Data)

Usage

Description

Protamine sulfate is a highly basic protein isolated from fish sperm that has various applications in the pharmaceutical, cosmetic, and personal care industries. It is known for its ability to neutralize heparin, a commonly used anticoagulant, and has a range of other biological activities.

Uses

Used in Personal Care and Cosmetic Applications:
Protamine sulfate is used as a conditioning agent in personal care products, such as hair conditioners and skin lotions, due to its ability to bind to and protect proteins and lipids in the skin and hair.
Used in Pharmaceutical Applications:
Protamine sulfate is used as an antidote for heparin overdose, as it acts as a heparin antagonist and neutralizes its anticoagulant effects. This makes it a crucial component in the management of bleeding complications associated with heparin therapy.
Used in DNA and Protein Research:
Protamine sulfate is used in molecular biology for the removal of DNA from protein samples or the purification of DNA binding proteins. Its polycationic nature allows it to bind to the negatively charged phosphate groups of DNA, facilitating separation and purification processes.
Used in Gene Transfer:
Protamine sulfate may be used as an alternative to polybrene in retroviral-mediated gene transfer, enhancing the efficiency of gene delivery into target cells.
Used in Antimicrobial Applications:
Protamine sulfate has antibacterial properties, making it useful in the development of antimicrobial agents and formulations.
Used in Pepsin Inhibition:
Protamine sulfate inhibits pepsin activity, which can be useful in the management of conditions related to excessive pepsin activity in the gastrointestinal tract.
Used in Complement System Regulation:
Protamine sulfate and other polycations have been shown to inhibit the classical pathway of the complement system, which can be relevant in the development of therapeutics targeting immune-related disorders.
Used in Lipoprotein Metabolism:
Protamine sulfate neutralizes the anticoagulant activity of heparin and inhibits the turnover of lipoproteins by lipoprotein lipase, which can be relevant in the study and treatment of lipid metabolism disorders.
Used in Erythrocyte Aggregation Studies:
The aggregation of erythrocytes in the presence of protamine sulfate has been investigated for its potential application in predicting MN phenotypes, which can be useful in genetic and epidemiological studies.