9014-81-7

Basic information

• Product Name: FETUIN
• Synonyms: FETUIN I BOVINE;FETUIN;FETUIN, BOVINE;FETUIN, FETAL BOVINE SERUM;fetuins;FETUIN FROM FETAL CALF SERUM*GAMMA-IRRAD IATED CELL;FETUIN FROM FETAL BOVINE SERUM CELL*CULT URE TESTED;Fetuin,Lyophilised
• CAS NO: 9014-81-7
• Molecular Formula: NULL
• Molecular Weight: 0
• EINECS: 232-762-7
• Product Categories: Cell Culture;Miscellaneous Reagents and Supplements;Reagents and Supplements;FetuinApplication Index;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents;Serum Proteins;Serum Proteins and Related Enzymes;Miscellaneous Plasma Proteins;Albumins and Transport Proteins;FetuinGlycobiology;GlycoproteinsApplication Index;Control Proteins for Glycosylation Studies;proteins
• Mol File: 9014-81-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: 2-8°C
• Solubility: H2O: 1 mg/mL
• Water Solubility: Soluble in water 1 mg/mL.
• CAS DataBase Reference: FETUIN(CAS DataBase Reference)
• NIST Chemistry Reference: FETUIN(9014-81-7)
• EPA Substance Registry System: FETUIN(9014-81-7)

Safety Data

• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 9014-81-7(Hazardous Substances Data)

Usage

Description

Fetuin, a 64 kDa plasma glycoprotein, is produced by the liver and adipose tissue. It possesses the ability to bind to the insulin receptor and inhibit insulin action, making it a significant protein in the study of type 2 diabetes mellitus (T2DM) and arterial calcification.

Uses

Used in Medical Research:
Fetuin is used as a biomarker in the study of type 2 diabetes mellitus (T2DM) for its significantly lower levels in patients with T2DM compared to control patients.
Used in Cardiovascular Research:
Fetuin is used as a protective agent in the development of arterial calcification, playing a crucial role in cardiovascular health.
Used in Pharmaceutical Development:
Fetuin is used as a target for the development of drugs and therapies aimed at managing insulin resistance and related conditions in type 2 diabetes mellitus.
Used in Diagnostics:
Fetuin can be used as a diagnostic tool to assess the risk of arterial calcification and related cardiovascular diseases.
Used in Drug Delivery Systems:
Fetuin's binding properties to the insulin receptor can be utilized in the development of targeted drug delivery systems for more effective treatment of type 2 diabetes mellitus and related conditions.
Used in Quality Control:
Fetuin can be used as a quality control standard for the assessment of insulin receptor binding affinity in pharmaceutical and biotechnological applications.
Used in Biochemical Research:
Fetuin's unique properties and functions can be further explored in biochemical research to understand its role in various physiological processes and potential applications in medicine.

Biochem/physiol Actions

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.