90151-10-3

Basic information

• Product Name: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE
• Synonyms: 4-METHOXYPICOLINAMIDE;4-METHOXYPYRIDINE-2-CARBOXAMIDE;4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE;4-Methoxypyridine-2-carboxamide 97%;2-Pyridinecarboxamide,4-methoxy-(9CI);Zinc00039322;2-Carbamoyl-4-methoxypyridine, 4-Methoxypicolinamide;4-Methoxypyridine-2-carboxamide97%
• CAS NO: 90151-10-3
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15
• Product Categories: AMIDE;blocks;Carboxes;Pyridines;Pyridine
• Mol File: 90151-10-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 149.3°C
• Boiling Point: 312.9 °C at 760 mmHg
• Flash Point: 143.1 °C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0.000513mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE(90151-10-3)
• EPA Substance Registry System: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE(90151-10-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 90151-10-3(Hazardous Substances Data)

Usage

General Description

4-Methoxy-pyridine-2-carboxylic acid amide is a chemical compound with the molecular formula C7H8N2O3. It is a derivative of pyridine and is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has a methoxy group and a carboxylic acid amide functional group, which make it useful for chemical reactions and as a building block for more complex compounds. It is also a potential ligand for metal complexes and may have applications in catalysis. However, it is important to handle this compound with caution as it may have harmful effects on human health and the environment.

InChI:InChI=1/C7H8N2O2/c1-11-5-2-3-9-6(4-5)7(8)10/h2-4H,1H3,(H2,8,10)

Upstream product

• 29681-43-4 methyl 4-methoxypicolinate 
• 620-08-6 4-methoxypyridine 
• 77287-34-4 formamide 
• 29082-91-5 4-methoxypyridine-2-carboxylic acid 

Downstream Products

• 10201-73-7 2-amino-4-methoxypyridine 

Relevant articles and documents

Synthesis method of imidazopyridine or pyrimidine derivative

The invention belongs to the technical field of synthesis, and particularly relates to a synthesis method of an imidazopyridine or pyrimidine derivative. The imidazopyridine or pyrimidine compound is obtained by taking pyridine or pyrimidinecarboxylic acid as a synthon through amidation, Hofmann degradation and cyclization reaction, and the obtained imidazopyridine or pyrimidine derivative can be further converted to generate a functional product. The method has the advantages of easily available raw materials, simple operation, high reaction efficiency, convenient post-treatment, and diversity of functional groups.

Method for synthesizing pyridine primary amides by direct catalytic oxidation process

The invention discloses a method for synthesizing pyridine primary amides by a direct catalytic oxidation process. The method comprises the following steps: under the action of acid or alkali, adding an accelerator water and an oxidizer into formamide which is used as a carbonyl source and nitrogen source, and catalytically oxidizing double C-H bonds of pyridine or derivatives thereof under the action of a silver and/or iron catalyst to directly prepare the pyridine primary amides. By activating the double C-H bonds, the method disclosed by the invention has the advantages of ideal atomic economy, less generated waste, wide and stable substrate sources, and low price. Under the optimized reaction conditions, the separation yield of the target products is up to 98%.