901765-36-4

Basic information

• Product Name: (5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-hydroxy-3-oxo-6-heptenoic acid ethyl ester
• Synonyms: (5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-hydroxy-3-oxo-6-heptenoic acid ethyl ester;(5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)aMino]-5-pyriMidinyl]-5-hyd;6-Heptenoic acid,7-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)aMino]-5-pyriMidinyl]-5-hydroxy-3-oxo-, ethyl ester, (5S,6E)-;(S,E)-Ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido) pyrimidin-5-yl)-5-hyd;(S,E)-Ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-h;(S,E)-Ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxy-3-oxohept-6-enoate
• CAS NO: 901765-36-4
• Molecular Formula: C₂₄H₃₀FN₃O₆S
• Molecular Weight: 508
• Mol File: 901765-36-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.291
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-hydroxy-3-oxo-6-heptenoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-hydroxy-3-oxo-6-heptenoic acid ethyl ester(901765-36-4)
• EPA Substance Registry System: (5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-hydroxy-3-oxo-6-heptenoic acid ethyl ester(901765-36-4)

Safety Data

• Hazardous Substances Data: 901765-36-4(Hazardous Substances Data)

Usage

Uses

901765-36-4 is a reagent in production of rosuvastatin.

Upstream product

• 890028-66-7 (E)-N-[4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-en-1-yl)pyrimidin-2-yl]-N-methyl methanesulfoneamide 
• 1030595-88-0 (S)-trans-ethyl 3-ethoxy-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxyhept-2,6-dienoate 
• 1045601-10-2 ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate 
• 89186-81-2 1-ethoxy-1,3-bis[(trimethylsilyl)oxy]buta-1,3-diene 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 851443-04-4 ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate 

Relevant articles and documents

Efficient and highly stereoselective assembly of rosuvastatin

We report an asymmetric synthesis of rosuvastatin starting from an α,β-unsaturated aldehyde precursor containing the rosuvastatin heterocyclic core at its terminus. The α,β-unsaturated carbonyl starting material was used in a highly stereoselective Ti-catalyzed aldol condensation followed by a syn-selective Narasaka–Prasad borane-ketone reduction and hydrolysis step to provide rosuvastatin calcium. This approach provides concise access to stereochemically pure rosuvastatin from simple and readily available starting materials in 3 steps. The overall three-step process provides rosuvastatin calcium in 80% yield, >99:1 syn/anti ratio, and >99% ee.

AN IMPROVED PROCESS FOR PREPARATION OF ROSUVASTATIN CALCIUM

The present invention relates to an improved process for preparing (E)-7-[4-(4-fluorophenyl)- 6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6- enoic acid calcium of Formula (I).