902454-25-5

Basic information

• Product Name: Piperidine, 1-methyl-4-[(4-nitrophenoxy)methyl]-
• CAS NO: 902454-25-5
• Molecular Formula: C13H18N2O3
• Molecular Weight: 250.298
• Mol File: 902454-25-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-methyl-4-[(4-nitrophenoxy)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-methyl-4-[(4-nitrophenoxy)methyl]-(902454-25-5)
• EPA Substance Registry System: Piperidine, 1-methyl-4-[(4-nitrophenoxy)methyl]-(902454-25-5)

Safety Data

• Hazardous Substances Data: 902454-25-5(Hazardous Substances Data)

Upstream product

• 20691-89-8 1-methyl-4-piperidinemethanol 
• 350-46-9 4-Fluoronitrobenzene 
• 24252-37-7 ethyl 1-methylisonipecotate 
• 1126-09-6 4-carbethoxypiperidine 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 1020204-50-5 3-chloro-N-(3-methyl-4-(4-methylpiperazin-1-yl)phenyl)-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-amine 
• 1020204-27-6 3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide 
• 1020206-18-1 N₁-(3-bromo-5-chloropyridin-2-yl)-6-((1-methylpiperidin-4-yl)methoxy)benzene-1,3-diamine 
• 1020206-17-0 3-bromo-5-chloro-N-(2-((1-methylpiperidin-4-yl)methoxy)-5-nitrophenyl)pyridin-2-amine 
• 1020206-16-9 4-((2-iodo-4-nitrophenoxy)methyl)-1-methylpiperidine 
• 902454-26-6 4-[(1-methylpiperidin-4-yl)methoxy]phenylamine 

Relevant articles and documents

4,6-DIAMINONICOTINAMIDE COMPOUND

[Problem] The present invention provides a 4,6-diaminonicotinamide compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for treating diseases caused by undesirable and/or abnormal cytokine signal transduction. [Means for Solution] The present inventors have extensively studied compounds having a JAK3 inhibitory action, and as a result, they have found that a 4,6-diaminonicotinamide compound which is the compound of the present invention has an excellent JAK3 inhibitory action and is useful as an agent for preventing or treating diseases caused by undesirable and/or abnormal cytokine signal transduction, thereby completing the present invention.

KINASE INHIBITORS

Compounds are provided for use with kinases that comprise a compound selected from the rou consistin of:wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods an intermediates useful for making the compounds; and methods of using said compounds.

Synthesis of new water-soluble DNA-binding subunits for analogues of the cytotoxic antibiotic CC-1065 and their prodrugs

Novel water-soluble indole-2-carboxylic acid derivatives (7, 13, 21 and 25) bearing a substituent with a tertiary amino functionality at C-5 have been prepared. These new DNA-binding subunits can be used for the synthesis of new analogues of the cytotoxic antibiotic CC-1065 and their corresponding prodrugs for antibody-directed enzyme prodrug therapy (ADEPT) within a selective treatment of cancer. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.