9025-39-2 Usage
Description
HEPARINASE, specifically Heparinase I from Flavobacterium heparinum, is an enzyme that plays a crucial role in the degradation and analysis of heparan sulfate, a glycosaminoglycan found in the extracellular matrix and on the cell surface. It is known for its ability to break down heparan sulfate, which is essential for various biological processes, including cell signaling, adhesion, and the regulation of angiogenesis.
Used in Medical Research:
HEPARINASE is used as a research tool for studying the role of heparan sulfate in various biological processes and diseases. Its ability to degrade heparan sulfate allows researchers to investigate the effects of this glycosaminoglycan on cell behavior and interactions with other molecules.
Used in Microbiology:
In the field of microbiology, HEPARINASE is used as an analytical tool for the digestion of plasma samples. This application aids in studying the effect of different factors, such as medium composition, washing, and sonication, on the infectivity of microorganisms like Chlamydia pneumoniae.
Used in Cancer Research:
HEPARINASE is used as an enzymatic agent for the removal of heparan sulfate from the surface of human rhabdomyosarcoma cells. This application is valuable in understanding the role of heparan sulfate in cancer progression and metastasis, as well as in developing potential therapeutic strategies targeting this glycosaminoglycan.
Biochem/physiol Actions
Heparinase I from Flavobacterium heparinum acts by cleaving the α-glycoside linkage at AT III binding site in heparin. This results in small oligosaccharide fragments and heparinase I neutralizes the protein′s action of anticoagulation. Therefore it might replace the use of protamine in reversing heparin induced anticoagulation after coronary artery bypass surgery. Heparinase I possesses a half-life of 15-18 minutes.
Check Digit Verification of cas no
The CAS Registry Mumber 9025-39-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,2 and 5 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 9025-39:
(6*9)+(5*0)+(4*2)+(3*5)+(2*3)+(1*9)=92
92 % 10 = 2
So 9025-39-2 is a valid CAS Registry Number.