90274-24-1 Usage
Description
Ractopamine hydrochloride is a phenethanolamine β-adrenergic agonist that functions by redirecting nutrients away from fat deposition and towards lean muscle deposition. It modulates metabolic pathways and signals in muscle and lipid cells to enhance protein accretion, and also regulates hormone release and modifies blood flow. Ractopamine hydrochloride is characterized as a white to off-white solid.
Uses
Used in Livestock Industry:
Ractopamine hydrochloride is used as a feed ingredient for cattle during the final days of finishing to improve feed efficiency and promote growth. It increases muscle mass and decreases body fat in rodents and livestock, making it an effective tool for enhancing the overall quality and marketability of meat products.
Used in Pharmaceutical Industry:
Ractopamine hydrochloride is used as an adrenergic β-agonist for its potential therapeutic applications, particularly in conditions where modulation of metabolic pathways and enhancement of protein accretion are beneficial. Its ability to regulate hormone release and modify blood flow may also contribute to its utility in various medical treatments.
Biological Functions
Ractopamine is a feed additive marketed by Elanco Animal Health in the US for swine (Paylean?), cattle (Optaflexx?), and turkeys (Topmax?). Zoetis also markets generic versions for swine (Engain?) and cattle (Actogain?). Ractopamine is intended to provide economic benefits by increasing rate of gain, improving feed efficiency, and increasing carcass leanness. The active ingredient is ractopamine hydrochloride, a synthetic, racemic biogenic amine, and a Beta-adrenoceptor agonists (β-agonists or beta-agonists). β-agonists are anabolic compounds that promote fat loss and muscle gain. It is not an antibiotic, hormone, or steroid.
Check Digit Verification of cas no
The CAS Registry Mumber 90274-24-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,2,7 and 4 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 90274-24:
(7*9)+(6*0)+(5*2)+(4*7)+(3*4)+(2*2)+(1*4)=121
121 % 10 = 1
So 90274-24-1 is a valid CAS Registry Number.
InChI:InChI=1/C18H23NO3.ClH/c1-13(2-3-14-4-8-16(20)9-5-14)19-12-18(22)15-6-10-17(21)11-7-15;/h4-11,13,18-22H,2-3,12H2,1H3;1H
90274-24-1Relevant articles and documents
PROCESS FOR THE PREPARATION OF RACTOPAMINE HYDROCHLORIDE VIA NOVEL INTERMEDIATES
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Page/Page column 10-13, (2020/11/30)
The present disclosure describes the new methods of preparation of Ractopamine which are superior to state of art by involving comparatively better and mild reaction conditions. The method of preparation involves following steps: In the first embodiment, 4-(4-hydroxyphenyl)-3-butene-2-one is prepared by condensation of 4-hydroxybenzaldehyde with acetone in the presence of sodium hydroxide/hydrochloric acid. In the next step, 4-(4-hydroxyphenyl)-3-butene-2-one undergoes hydrozination with 4-(-2-amino-1- hydroxyl ethyl) phenolhydrochloride in the presence of base using Pd/C/H2 as a catalyst in methanol/ethanol as solvent to yield Ractopamine base. In another embodiment, advancement over the previous scheme is use of Raney Ni/H2 instead of Pd/C as a catalyst. In yet another embodiment, 2-amino-1-(4-hydroxyphenyl) ethanone hydrochloride reacts with 4-(4-hydroxyphenyl)-butane -2-one in the presence of base and raney nickel/H2 as a catalyst. Compared to the prior art reports where Pd/C was used as a catalyst, Raney Ni is used in the present embodiment which is comparatively economical and better catalyst.