904086-06-2

Basic information

• Product Name: 3'-(METHYLTHIO)-1,1'-BIPHENYL-4-OL
• Synonyms: 3'-(METHYLTHIO)-1,1'-BIPHENYL-4-OL
• CAS NO: 904086-06-2
• Molecular Formula: C13H12OS
• Molecular Weight: 216.29878
• Mol File: 904086-06-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 376.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• PKA: 9.75±0.26(Predicted)
• CAS DataBase Reference: 3'-(METHYLTHIO)-1,1'-BIPHENYL-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-(METHYLTHIO)-1,1'-BIPHENYL-4-OL(904086-06-2)
• EPA Substance Registry System: 3'-(METHYLTHIO)-1,1'-BIPHENYL-4-OL(904086-06-2)

Safety Data

• Hazardous Substances Data: 904086-06-2(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 25244-30-8 4-(allyloxy)bromobenzene 
• 128312-11-8 3-methylthiophenylboronic acid 

Relevant articles and documents

Design, synthesis, and anti-proliferative evaluation of [1,1′-biphenyl]-4-ols as inhibitor of HUVEC migration and tube formation

Allylated biphenol neolignans contain a variety of chemopreventive entities that have been used as anti-tumor drug leads. Herein, 37 allylated biphenols were evaluated for anti-proliferative activity by the MTT assay and inhibitory effect on the migration and tube formation of HUVECs featuring anti-angiogenic properties. 3-(2-Methylbut-3-en-2-yl)-3′,5′-bis(trifluoromethyl)-[1, 1′-biphenyl]-4-ol (5c) exerted an inhibitory effect on HUVECs compared to honokiol (IC50 = 47.0 vs. 52.6 μM) and showed significant blocking effects on the proliferation of C26, Hela, K562, A549, and HepG2 (IC 50 = 15.0, 25.0, 21.2, 29.5, and 13.0 μM, respectively), superior to those of honokiol (IC50 = 65.1, 62.0, 42.0, 75.0, and 55.4 μM, respectively). Importantly, compound 5c inhibited the migration and capillary-like tube formation of HUVECs in vitro.